Hepatic insulin clearance in patients with hyperte

e707004304 · Wysłany: Śro 13:46, 16 Mar 2011

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The liver of patients with hypertension changes in insulin clearance

The corresponding area under the curve calculation (AUC) and the Cp / Ins ratio. AUC = ÷ (+3 hours of empty Yu value value) value + 2 hours + 1 hour values. 4. Data processing: parameter to E4-, said. Or a value with the test,[link widoczny dla zalogowanych], the P value was significant,[link widoczny dla zalogowanych], said. Preparation of the original value of the non-normal distribution. Natural logarithm is involution. The results of a high incidence of pancreatic tangled hyperlipidemia: impaired glucose tolerance: blood pressure category,[link widoczny dla zalogowanych], 7O (42/60), control group 6.25 (2 / 32). The fasting blood glucose of islet tangled over 75 is defined as high normal islet tangled hyperlipidemia (fasting insulin> 8.19 ~ U / L>. Hypertension incidence was 66.67 (40/60). The control group 12 .5 (4 / 32). Second,[link widoczny dla zalogowanych], changes in glucose tolerance: seek Table 1. show hypertension than Cp / Ins AUC than the control group and outside (P <O.001) - the rest of the values were significantly higher than the control group increased. hypertension islet tangled, c peptide for 120 minutes at the peak. 6O minutes from the control group. Table 1 hypertension group and control group, blood glucose, insulin Green, C 64-D shoes belly than the note, with the Black group P <O.ool ** P <0-05 * Postal Code Iz15oo6 three isradipine blood pressure changes after 4 weeks of treatment: systolic blood pressure from 23.1l ± 2 .. 71kPa who dropped 19.oo 1.80kPa, diastolic blood pressure decreased from 13.68 ~ 1.40kPa II.10hE1.80kPa (Pd0.001) Fourth, changes in glucose tolerance after isradipine treatment in Table 2. shows Cp / Ins ratio of AUC in the treatment of no significant changes before and after} the rest of the values were significantly decreased (P <. .01), but the values were not restored to normal levels. Table 235, in South OGTT pressure changes in patients before and after treatment (; disabilities) Note t dip compared with the treatment of · P <0.0Ol on recent clinical hypertension has been noted that high blood pressure than patients, but also to the performance characteristic of insulin resistance and blood lipid disorders and promote atherosclerosis risk factors increases [1]. In this paper 60 cases of high The results show the patients blood pressure, blood glucose, insulin, C peptide concentration and AUC were significantly increased, indicating the existence of insulin resistance in hypertension, confirmed the report [2]. C peptide is the activity of proinsulin into insulin and other polypeptides produced mainly by the kidneys than holding, without degradation in the liver from the portal vein insulin} about half of the hepatic degradation here, C belly / insulin ratio may reflect the matrix of liver to insulin degradation situation]. In patients such as cirrhosis of liver cell damage by ['], due to atrophy and reduce the number of liver cells, affecting the degradation of insulin receptor-mediated l and the reduction of endoplasmic reticulum and mitochondrial condensation, caused by the degrading enzyme system reduced to the liver to insulin degradation rate decreased, Cp / Ins dropped significantly. this group of hypertensive patients with normal liver function, but the C peptide / insulin ratio was significantly lower than the control group, indicating that the degradation of insulin in patients with hypertension to reduce the liver, new study abroad, this phenomenon also found the small coffee. Salvatore so different dose of glucose and insulin were shown to the small liver of patients with essential hypertension there is decreased insulin clearance and decreased insulin clearance made one of the characteristics of hypertension's views, but the exact mechanism is unclear. Isradipine is a effective blood pressure lowering drugs, has little impact on glucose metabolism, our results show significantly reduced their blood pressure, blood glucose, insulin and C peptide concentrations, but the Cp / Ins ratio did not change, suggesting that it can not change the hepatic clearance of insulin, The lower hepatic insulin clearance rate of hypertension may be the main reason for primary metabolism. So hyperinsulinemia with hypertension have more than islet cells other than the mouth, the liver clearance of insulin is also the reason for the decline in one.