IL-6 and CRP in early diagnosis of neonatal sepsis

ncycgdxhl · Wysłany: Nie 22:23, 27 Mar 2011

IL-6 and CRP in early diagnosis of neonatal sepsis in the clinical study

Occult disease , clinical symptoms are nonspecific , so early in the clinical diagnosis of sepsis is very difficult. The prognosis of sepsis depends on early and effective antibiotic treatment, but inappropriate antibiotic treatment can also lead to overuse of antibiotics . So . Early diagnosis of neonatal sepsis have a more important clinical significance. Interleukin- 6 (IL-6) is the host inflammatory response early on the importance of the media , it is invasion of the body in a few hours after bacterial infection reached a peak . Changes of serum IL_6 common infections is very small , and only in severe infections have increased significantly. Sepsis in this group (which includes confirmed cases and clinically diagnosed cases ) in serum II, -6 level was 68.5 ± 24.1ng / L,[link widoczny dla zalogowanych], control group was 35.8 ± l1.4ng / L, the two groups was significant Differences. The control group 95% nT The results show that , II, _6 early diagnosis of bacterial infections have a higher sensitivity (87 %) and specificity (82.9 %), can be used as an indicator of early diagnosis of neonatal sepsis . CRP is a protein in tissue injury in acute phase response , is under stress the body by the liver in the synthesis of acute phase proteins by cytokines such as II plant -6, TNF triggered. Neonates with bacterial infections was significantly higher CRP , usually within 24 hours of infection increases, can be used as indicators of early diagnosis of neonatal sepsis, p, 41. The results show that this group , CRP high specificity ( 88.6 , but low sensitivity (60.8% o so when combined with testing in the detection IL_6 CRP, can further improve the diagnosis of neonatal sepsis . IL - 6 and CRP Is a better predictor of neonatal sepsis , especially IL_6, is a sensitive marker of early bacterial infection , the treatment plan to improve the prognosis important reference .