Mechanism of liver caused by stasis _4652

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Mechanism of liver caused by blood stasis

Reduced substances, its mechanism is inhibition of adenylyl cyclase activity, cAMP levels in the cells, thereby promoting platelet aggregation,[link widoczny dla zalogowanych], vasoconstriction. And TXB contrast, prostacyclin (PGIz) is known to inhibit platelet aggregation most effective material and vasodilators, the mechanism is by stimulating cellular adenylyl cyclase, increased cAMP levels, on platelet aggregation, vascular tone and thrombosis play an important regulatory role 0]. We reported before, the liver rat model of liver, blood lipid peroxidation enhanced increased vasospasm, thrombosis speed ridicule. visible blood stasis and plasma TXA-PGI: balance disorders are closely related. PGIz observed in this study and the stability of metabolites of TXA 6 a keto - PGF-and TXB2 changes to reflect the TXA : - PGI level]. The results suggest that: the increase of liver rat model of TXB2 and 6 keto-PGF1l a decrease, TXB2 / 6 of a keto - PGF. the imbalance is an important part of the mechanism causes blood stasis. cells through the cell membrane to regulate the environment inside the cell and between cells and to each other. erythrocyte membrane lipid bilayer structure (phospholipids, cholesterol, glycolipids), red blood cell membranes because of its rich in unsaturated fatty acids , is directly exposed to high oxygen partial pressure, it is prone to lipid peroxidation. The results show that: rat model of liver cell membrane fluidity decreased significantly. may be related to the strength of lipid peroxidation, liver large mouse model of enhanced lipid peroxidation product of free radical intermediate Ⅲ and the final product malondialdehyde serious injury of membrane structure and membrane fluidity, the membrane fragility, resulting in membrane dysfunction Ⅲ. erythrocyte membrane fluidity and red cell deformation capacity. It affects the blood flow is an important factor. erythrocyte membrane fluidity may also be reduced with the TXA - PGI related disorders. PGIz secretion decreased, TXA: increase, which in turn activate the secondary platelets, causing platelet endothelial cells and cGMP to reduce the increase in cAMP, cAMP-cGMP-conditioning system imbalance in recent years the can reduce the deformation of red blood cells decreased. microcirculation leading to easy formation of microthrombi 0] stasis of their membrane microviscosity increased, decreased mobility, whether animal or blood stasis model changes in blood stasis syndrome is the clinical consistent with ridicule. visible red cell membrane fluidity is closely related with blood stasis syndrome. erythrocyte membrane fluidity in liver caused by decreased blood stasis is one of the pathogenesis of this study suggest Xiaoyaosan liver with reduced plasma TXB: concentration, increased by 6 a ket0 a PGF1l level, thereby regulating TXBz / 6 of a keto - PGF1. balanced and have improved i erythrocyte membrane fluidity in liver function. explain their causes or induced liver blood stasis tend to have preventive effects. disproof of the Liver To the theory of stasis is stasis} and from the liver, liver qi stagnation with blood stasis treatment provides the basis for prescriptions. References 1 Qiaoming Qi. qi inverse, objective indicators qi depression experimental study of two cards. Shandong College of .1992 , (3) :23-25.2 with you. motherland medicine, Traditional Chinese Medicine. 1989. (6) :18-2o. 3 ZHOU Yong-chang, Weng Zhi. A balance of TXA2 and PGI2 clinical. Journal of Internal Medicine, 1987. (1) :49-52.4 DRUG DEPENDENCE, Liu Cheng before. Huang Clinical and Experimental Research. Traditional Chinese Medicine .1991.32 (1. 1:48 - 48.6 Wang Lei,[link widoczny dla zalogowanych], Liu Cheng only. that the section of liver blood theoretical and experimental research. Shandong University of Chinese Medicine, 1994.18 (2): 91-93.7 Shu Shouqin. pro-Alice, Li Zhu .27 kinds of Chinese medicine and SOD on lipid peroxidation in vitro rat homogenate shadow Health Qi I to. Shandong University of Chinese Medicine, 1991,[link widoczny dla zalogowanych], (3) :72-73 .8 Shi Lin. Danshen with fluorescence polarization study orderly platelet membrane lipid fluidity of the impact. Pharmacology and Clinical .1985. inaugural issue of the rule 101.9 Tan Yu Xie box and in the membrane fluidity of Health medical research. Traditional Chinese Medicine Magazine, 1992,[link widoczny dla zalogowanych],12 (11) :899-701