MAC Cosmetics UK High CO2 on the invasion of gastr

43nike9485qt · Wysłany: Nie 11:37, 20 Mar 2011

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High CO2 on the invasion of gastric cancer cells

Invaded the serosa ,[link widoczny dla zalogowanych], and laparoscopic surgery of gastric cancer cells in long-term exposure during pneumoperitoneum environment on CO , CO pneumoperitoneum is to promote peritoneal metastasis of gastric cancer cells is not clear. Progress at home and abroad because of laparoscopic radical operation for gastric cancer carried out a short time, less the number of cases ,[link widoczny dla zalogowanych], research has not been reported. Therefore, CO -depth study of pneumoperitoneum on gastric cancer cell invasion and metastasis of abdominal cavity , and to explore its possible mechanism of laparoscopic radical operation for the further development of gastric cancer has important clinical significance and practical value. MMP2 and MMP9 are matrix metalloproteinases (MMPs) gelatinase family . MMPs are a series of biodegradable extracellular matrix and basement membrane endopeptidases , collectively, in tumor invasion , not only created the collapse of the extracellular matrix of the channel , but also the rearrangement of the extracellular matrix , and thus conducive to tumor cells Out . Has been demonstrated , MMP2 and MMtO tumor invasion and metastasis in a variety of process have played an important role. Many on the expression of MMPs in different tumor studies show that , MMP2 and MMP9 expression in tumor tissue was significantly higher ,[link widoczny dla zalogowanych], and its high expression and histological grade of tumor cells , invasion and lymph node metastasis reproductive capacity was significantly correlated . Based on the above analysis, we chose the high invasiveness of MKN45 human gastric cancer cell lines , high-pressure CO flow cytometry on human gastric cancer cell lines MKN45 and MMPO expression of MMP2 in vitro observation of high-pressure CO, and duration of gastric cancer cells at different times and MMP2 MMIO expression to observe the pneumoperitoneum invasion of gastric cancer cell adhesion changes. The results show that CO: pressures up to 25mmHg, lasts longer than 1 hour, gastric cancer cell MMP2 and MMP9 expression was significantly increased, thus confirming the high-pressure CO on gastric cancer cell invasion may have an impact, so that gastric cancer cell invasion and metastasis ability Are enhanced. From this we can speculate that patients with gastric cancer laparoscopic high pressure CO increased risk of metastasis and recurrence after surgery .
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