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yxfbbiedtj · Wysłany: Śro 13:43, 09 Mar 2011

Beijing part of the urban elderly patients with chronic renal insufficiency prevalence and etiology of

Months, 16 patients had no renal decompensation Performance (2) non-elderly group of nephrotic syndrome: 36 cases. Hospitalized patients for the same period 20 males and 16 females; aged 15 to 58 years, an average of 35 years. Living La renal pathological types: mesangial proliferative glomerulonephritis in 16 cases,[link widoczny dla zalogowanych], 9 cases of membranous nephropathy, membranoproliferative glomerulonephritis in 8 cases,[link widoczny dla zalogowanych], focal segmental glomerulosclerosis in 3 cases of l students. Course of 05 to 42 months. (3) healthy control group: 3O cases of healthy examination. Male l6 cases. 14 females; age of 60 ~ 7l years. Average 6,1.6 years. Renal biopsy 8 healthy controls set down for bone grafting healthy kidney donors before kidney. Methods: (1) flow cytometry on peripheral blood CD62P: isothiocyanate yellow pigment (FITc) monoclonal antibodies cD62P (mouse anti-human antibody) and negative control antibody goat anti-mouse IgG1FITC. Are the method Author: 250,213】 crowded Nanshi,[link widoczny dla zalogowanych], the PLA Jinan Military General Hospital, Department of Nephrology 【Aiping, Wang Yanxia, Liang Junlin), where cell room f MEDICINE IN Xiaoming Sun) Governor to take on the summary selectin expression b8-2 a country Immune flow cytometry of international products: FACScan, or American BectonDickison company. Blood sample processing and flow cytometry procedure see ref 21]. (2) renal biopsy determination of CD62P expression: direct immunofluorescence using frozen section method. Second,[link widoczny dla zalogowanych], the results 1. CD62P expression in peripheral blood: Nephrotic syndrome group cD62P old expression level (9.8 ± 2 Cool

, and the healthy control group f33 ± 1,1), the difference was significant test (below),[link widoczny dla zalogowanych], cadaverine <001] ; nephrotic syndrome and non-elderly group (7,1 ± 2.6) compared. There were significant differences (P <0.05). 2, CD62P expression in kidney: nephrotic syndrome patients aged 6 down mesangial proliferative glomerulonephritis in the 4 fell expression. 5 cases of membranous nephropathy, membranoproliferative glomerulonephritis in 3 cases, 2 cases of focal segmental glomerulosclerosis was expressed that the 16 cases, 14 cases in renal tissue (875); expression of a number between f a) ~ (+ a +); expression sites prevalent in the glomerular mesangial area and capillary loop. Followed by tubular and interstitial small vessel wall, and the expression of CD52P and renal pathology of the disease site location and extent consistent with sex abuse (Figure 1). Non-elderly group of 36 patients with nephrotic syndrome renal expression of CD62P and older parts of intrinsic renal comprehensive set of basic units the same, but weaker expression in renal tissue of healthy control group is no cD62P expression. Third, the discussion revolves P selectin adhesion molecule selectin is in one of three major components. Cell-mediated neutral offerings and single plant cells to endothelial cells and activated platelets, revolves attached. And as a surface marker of activation of the latter. Recent studies show that in immune recognition, inflammation, hypercoagulable state, thrombosis play an important role of processes:. Elderly patients with nephrotic syndrome around 1 Tim Tan pathology of renal mesangial proliferative glomerulonephritis-CD62P in renal mesangial Stanford Carpenter, tubular expression of ten. Direct immunofluorescence linked × 200 elderly patients with an immune disorder nephrotic syndrome, emblem vascular disease, hypercoagulable state and thrombosis. Most have been associated with atherosclerosis and arterial wall thickening, Mu narrow tube, in the event of nephrotic syndrome is more significant disease, cD62P as an important substance involved in inflammation and the role of activated platelets. . EMU elderly patients with nephrotic syndrome and renal tissue in peripheral blood were significantly higher CD62P expression, the expression in the kidney area and extent of pathological damage consistent, suggesting cD62P 』in the elderly, nephrotic syndrome has an important role in the pathogenesis of this disease hypercoagulable state and inflammatory response to injury in the diagnosis and treatment is of great significance