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ORANGE EKSTRAKLASA
Dołączył: 22 Lip 2010
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 Wysłany: Sob 7:57, 26 Mar 2011 |
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Batroxobin edaravone combined treatment of progressive cerebral infarction
Restrictions, not more than thrombolytic therapy . DF Di defibrase pod is able to directly degrade fibrinogen in the blood , activating endothelial secretion of endogenous tissue-type plasminogen activator (t-PA), reduce the intensification of the plasma protease inhibitor activity , and enhance Protease active fibers , to thrombolysis , reduce platelet aggregation and adhesion Majesty , so has a lower fiber , thrombolysis, anticoagulation effect of the Air J. After acute cerebral vascular occlusion caused by hypoxic ischemic brain tissue , resulting in ischemia and ischemic center around the penumbra, blood flow can lead to ischemia and reperfusion after ischemia reperfusion injury cascade , including energy Metabolic abnormalities , acidosis,[link widoczny dla zalogowanych], release of excitatory neurotransmitters , excessive influx of calcium ,[link widoczny dla zalogowanych], free radical -mediated toxicity. Free radicals which cause brain damage is the direct cause of apoptosis . Thus , scavenging free radicals ,[link widoczny dla zalogowanych], breaking the reaction chain is the basic guarantee of successful treatment . Edaravone is a potent free radical scavengers and antioxidants , can inhibit xanthine oxidase and hypoxanthine oxidase activity and stimulate the formation of prostacyclin cable ,[link widoczny dla zalogowanych], reducing the generation of inflammatory mediators leukotrienes ,[link widoczny dla zalogowanych], reduce The concentration of hydroxyl radicals , reducing the development of ischemic penumbra or infarct volume and inhibit delayed neuronal death 【 3]. Edaravone small molecular weight, blood-brain barrier permeability of up to 60 %, after intravenous injection of direct ischemic penumbra to prevent the progress of infarction . In addition, edaravone does not affect blood coagulation , fibrinolysis, platelet aggregation without increasing the risk of bleeding HJ. Takabatake , etc. J, combined with ozagrel edaravone treatment of acute cerebral infarction , showing two drugs than alone can improve the efficacy of edaravone .
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