mbt italia 44 cases of fungal keratoconjunctivitis

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44 cases of fungal keratoconjunctivitis in patients with fungal culture and sensitivity test result analysis

Beijing Institute of Ophthalmology, l1 months to microbial room for eye clinic inspection I10 specimens were fungal culture, of which 44 patients with positive fungal culture,[link widoczny dla zalogowanych], and focus on the recent use of antifungal natamycin and terbinafine were phenol 【drug sensitivity tests, the results reported below. I Materials and Methods 1. I generally superfluous material in August 1998 to January Tongren Hospital eye clinic l1 suspected fungal eye infections, fungal culture samples I10 cases of censorship, in which parallel culture positive fungal susceptibility testing of 44 patients, male 3o, female 14 cases. 44 cases of corneal specimens from 42 patients, 2 cases of conjunctival specimens. I. 2 Methods fungal culture by routine culture tube method of sand culture weak security, according to morphological characteristics distinguish the genus. Drug sensitivity test by disc method, subjects drugs, including: phenol terbinafine, natamycin and clotrimazole. 2 Results 2. Yin is identified in Table I I. 144 Huan teach life drug test given 2.2 mantis shown in Table 2. 11 of 244 wall atlas feeding really positive awaken buried a car Lu ■ t of grapes Fu 【%) Author: Shen, Beijing Institute of Ophthalmology, Biology I Room (100730) 22 feet of a / _>) a} / 3 of the discussion on 44 cases of fungal culture genus of positive samples found that the most common of the observation period for the Fusarium genus, accounting for 61.4%,[link widoczny dla zalogowanych], followed by non-spore genus, accounting for 22.7%, while the other three genera '3 relatively small】. Susceptibility test results showed that 88% of culture-positive bacteria sensitive to natamycin, 54.5% culture-positive bacteria sensitive to Terbinafine. In the 27 cases identified in Fusarium,[link widoczny dla zalogowanych], natamycin sensitivity of 26 strains, 96.3%. Phenol on terbinafine-sensitive and 12 strains, 44.4%, while only I clotrimazole-sensitive strains, accounting for 3.7%. No spores in 10 cases, 9 cases of natamycin sensitive to Terbinafine sensitivity of 9 cases, 6 cases of clotrimazole sensitive. Analysis, we found 5 cases of natamycin resistant in 2 cases of Terbinafine sensitive, 4 cases of clotrimazole sensitive. Natamycin is a polyene alcohols large ring of antibiotics, by interfering with fungal cell membrane synthesis of steroid compounds, inhibit or kill fungi play a role. This drug from foreign sources as first-line treatment of fungal keratitis, one of the drug is seldom used currently. Particularly resistant to phenol than the allylamine class of antifungal agents, by inhibiting ergosterol synthesis of squalene in the process of COX-tim,[link widoczny dla zalogowanych], so that accumulation of po-ene, to sterilization, as well as broad-spectrum antifungal agents. Since the sensitivity of human cells for the fungus to its ten-thousandth, so relatively safe '4 J. With respect to clinical azole antifungal agents commonly used terms such as clotrimazole, especially compared with natamycin resistant strains resistant to phenol less, the results from the laboratory point of view may be sensitive treatment of fungal keratitis caused by the effective drugs. 4
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