mbt schoenen online kopen Metoprolol and 98 patien

lin06900 · Wysłany: Pią 11:35, 25 Mar 2011

Metoprolol and 98 patients with aspirin treatment of migraine

Lol, aspirin combined therapy of migraine with the exact results. Key words migraine; metoprolol; of aspirin CLC R747.2 Document code B I hospital outpatient December 2004 ~ March 2007 Ⅱ according to ICHD an international diagnostic criteria [1 diagnosis of migraine 98 cases, the use of metoprolol and aspirin therapy, and achieved good results, are as follows. 1 Data and methods 1.1 General information on 98 patients with migraine in male 17, female 81 cases. Age 18 to 68 years, mean 38.6 years old. Duration of 3 months to 20 years. Episode 3 to 5 times in 9 cases, 5 to 10 times in 41 cases,> 10 48. 1.2 The nature of clinical manifestations of pulsating throbbing headache,[link widoczny dla zalogowanych], pain,[link widoczny dla zalogowanych], sometimes accompanied by symptoms of autonomic dysfunction,[link widoczny dla zalogowanych], including migraine without aura in 79 cases, 1 case of complicated migraine, migraine with aura in 18 patients. No headache continuous state case. Threatened means the occurrence of headache occurred before the fully reversible focal neurological symptoms, mostly visual symptoms, sensory symptoms mostly regional distribution of one hand. Aura symptoms are formed in 5-20 minutes, sustained less than 60 minutes, can be of different sign spate ¨ 2l. 1.3 Treatment of metoprolol succinate 23.75mg / times, aspirin 150mg / time, 1 to 2 times, and even served 5 days of metoprolol succinate 47.5rag / time, 1 day 2 (heart rate slower than 60 beats / min without dose), aspirin 100m ~ times, 1, 1,[link widoczny dla zalogowanych], 3 months to 1 course of treatment. March immediately after treatment with metoprolol should not be discontinued, continued reduction of 1 to 2 weeks after withdrawal. 1.4 Results After treatment, headache and associated symptoms disappear. 1 year 82 cases without recurrence (83.7%). Significantly reduce headache and associated symptoms,[link widoczny dla zalogowanych], recurrence within 1 year after treatment was significantly reduced compared with the previous month <1, and the pain each time asked the short, mild symptoms over the previous 11 cases (11.2%). 2 cases of adverse reactions due to aspirin appears not adhere to the full course of treatment, other patients without serious side effects. 2 is a discussion of migraine attacks of vasomotor dysfunction, headache, seizures increased platelet aggregation, release 5, a serotonin (5 a HT) induced cerebral vasoconstriction, to be degradation of 5-HT metabolism in brain blood vessels to dilate. 5-HT has two-way effect on vascular smooth muscle, the plasma 5-HT levels decreased, causing contraction of small arteries, large arteries dilate. During migraine attacks ,5-lit with histamine, bradykinin and other substances common role of neuropeptide produced headache ¨ l1. Metoprolol is used as a selective p-blocker treatment of migraine headaches, can inhibit the cortical surface in the early onset of small-artery spasm, inhibit the reaction of exacerbation of cerebral vasodilation. Is a long-acting metoprolol succinate B receptor blockers, the role for 24 hours, better prevention and treatment of migraine drugs. Aspirin inhibits platelet aggregation and ADP release, but also inhibition of prostaglandin synthesis, which has a strong analgesic effect, for the early onset of migraine and the attack, and rapid inhibition of headache [31. The group of metoprolol, aspirin combination therapy and after 1, accompanied by headache or headache symptoms were relieved the symptoms disappeared in 81 cases (82.7%), no recurrence within 1 year, 82 cases (83.7%). That metoprolol and synergistic effect of aspirin, which can effectively relieve symptoms quickly and prevent recurrence. Aspirin alone on clinical pain, B-blocker treatment of migraine alone, effects are not ideal, as two-drug combination. Migraine most easy to relapse, triggers and more comprehensive treatment should be more rest, eat fruit, avoid the emotional stimuli, to maintain peace of mind. The group used aspirin, metoprolol and maintenance in March, aimed at prevention of migraine recurrence, the results are satisfactory, is worthy of further exploration.
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