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asbryobvrz · Wysłany: Pią 11:15, 18 Mar 2011

Urticaria induced by intravenous infusion of ATP in 2 cases

# 183; 127 * multiple large areas of skin and limbs like changes in the wind group, slightly higher than the skin, the pressure of the non-fading, consider urticaria, that discontinuation of the infusion, give isoproterenol cried 25mg, dexamethasone 10mg, im, 40min After the rash disappears. Group 3 again the next day intravenous infusion of the rash appears Shiyou infusion, while patients with self-inductance of chest tightness, suffocation, then stop infusion, give isoproterenol cried 25mg, dexamethasone 10mg, im, about the symptoms 30min, 1h after the rash disappears . Disabled patients after ATP, Pantone injection caused any adverse reactions in 3 cases Liang Jianhua Sui Ping (Beijing Ji Shui Tan Hospital, Beijing 100035, China) Example 1, female, 79 years old, due to diabetes, cerebral infarction after admission, to give intravenous injection Pantone, 300mg / d treatment, the same day delivery symptoms of abdominal pain and diarrhea (4 to 6 times a day of diarrhea), drip rate will slow down (from 40 drops / min to 20 drops / min), abdominal pain and a little relieved. Intravenous infusion of the drug in the whole process, the continuing symptoms of abdominal pain and diarrhea, were still capable of tolerance,[link widoczny dla zalogowanych], it did not stop. Patients during intravenous infusion of Pantone, while serving metformin 1:3 every time 250rag,[link widoczny dla zalogowanych], each Fi2 ~ 3 times the amount adjusted according to glycemic index. Pantone disabled after injection, no recurrence of the symptoms. Example 2, male, 85 years old, due to cerebral infarction, pulmonary infection after admission, to give intravenous injection Pantone 100mg / d treatment, the drug began to appear that evening the body rash, disable, Pantone, the anti-allergy Xian Temin therapy, 2d, the body rash fades. Example 3, male, 64 years old, due to cerebral infarction, pneumonia, hospitalization, given intravenous injection Pantone, 100mg / d treatment, medication 2h, were the trunk, limbs, facial erythema, wheal, symmetrical distribution of lesions , accompanied by itching, general discomfort,[link widoczny dla zalogowanych], the clinical diagnosis of drug-induced urticaria, immediate withdrawal, to be 1:3 clothes allergy Xian Temin, vitamin C, menthol phenol topical lotion, the condition improved. 3 cases of adverse reactions discussed above, are elderly patients, no history of drug allergy, both in the use of Pantone gastrointestinal symptoms and skin after allergic reactions, and hence the causal relationship between Pantone clear. Pantone injection containing pentoxifylline (Pentoxifytline) 100mg, for the cerebral circulation and peripheral vascular disorder improving agent, can restore and enhance the deformability of red blood cells to increase their filtration, increased fibrinolytic activity, decreased plasma viscosity degree of inhibition of platelet aggregation,[link widoczny dla zalogowanych], thereby increasing the flow of arteries and capillaries, improve the rest of the brain and continue to intravenous drugs, the symptoms did not arise again. Discuss the two cases described above were pruritus, urticaria and other adverse reactions, Department A1] P caused prompt before using the ATP should be asked in detail about past history of allergies in patients with allergies or try not to be used with caution; in the use of A1] P should be closely observed, in the event of adverse reactions, immediately discontinued and symptomatic treatment. Limbs of the blood circulation. At the same time have the goods on bronchial smooth muscle relaxation. Mainly for: ① brain blood flow barriers, such as transient ischemic attack, stroke caused by side effects. ② peripheral blood flow disorders, such as thromboangiitis obliterans, ocular blood flow disorder. ③ inner ear function disorders, such as age-related hearing loss and tinnitus. This product is dose-related adverse reactions, and often involving the gastrointestinal tract, nausea and indigestion from the bow l,[link widoczny dla zalogowanych], flatulence, loss of appetite and vomiting. Initial dose of 100mg pentoxifylline, intravenous drip infusion time should be reached when 90 ~ 180min. Maximum drip rate not faster than 100mg / h. According to the daily increase patient tolerance to 50ms, each dosage should not exceed 300rag. Available in different conditions 1 or 2 times a day. 1 patient the dose was 300mg / d, which for the first time, larger doses of medication in older patients, and the drip rate slightly faster and therefore gastrointestinal reactions occurred when the infusion rate adjusted after the symptoms have eased, disappeared after drug withdrawal. Patients due to long-term diabetes, while metformin. Adverse reactions are gastrointestinal system which can be diarrhea. Pantone and insulin can stimulate the release of the drug can enhance the effect. Therefore, these adverse reactions may be due to the synergy of two drugs caused. Pantone yellow cast a glance for the third generation of methotrexate derivatives, methotrexate has a yellow cast a glance allergens cause the first 2 cases and 3 patients may be a xanthine allergies, therefore there systemic allergic reactions. The product can also cause central nervous system and cardiovascular system adverse events, fatal aplastic anemia were occasionally heard. Pantone hospital use by the German production, in our time to market soon, information about efficacy and fewer adverse reactions, it should prompt close observation of clinical applications, to ensure their safety and effectiveness.