Clinical acute organophosphorus pesticide poisonin

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Acute clinical analysis of organophosphorus pesticide poisoning

Continued existence of poisoning gastrointestinal absorption and enterohepatic recycling secretion. Most patients in this group were rescued in the early application of pralidoxime, severe first dose of 1g intravenous injection, and then to 0.5 ~ 1.0g / h continuous intravenous infusion of medication, reached a total of 1O ~ 16g / d, used in conjunction 2 ~ 3d, atropine also achieved better clinical results, including 1 case of high-dose pralidoxime IMS is still valid and death. We believe that the increase of dichlorvos and other poisoning agents can be detrimental to recovery, while dimethoate and malathion poisoning can use the recovery agent needs further study. Oxime compounds should not be confined within 72h after poisoning, should make full use of the drug and non-re-re-activation of the activation effect [5], helps to restore spontaneous breathing patients with respiratory failure. Sorption hemoperfusion with a broad spectrum of molecular weight, height and fat-soluble toxic protein binding can be used with high [Citation. Organophosphorus pesticides easily combined with proteins in the body, and the molecular weight of large, high-fat-soluble, such as can not easily be removed by dialysis,[link widoczny dla zalogowanych], and clear the effect of blood perfusion [7]. Organophosphorus pesticide poisoning were a tremendous superiority of blood perfusion, and perfusion time of the earlier (<6h), the blood clearance of toxins are adsorbed to the more toxic the amount distributed to 全身各器官 less, for organ the more light damage. Literature Is] reports that hemoperfusion decreased mortality, duration of coma, time of atropine and cholinesterase activity were significantly shortened recovery time. In the blood perfusion in the normal blood components such as platelets, white blood cells, clotting factors, glucose, and the use of divalent cation of atropine, chlorine adsorption of phosphorus removal can also be determined, but is available to monitor and supplement, without the side effects . The group, 3 cases of severe organophosphorus pesticide poisoning patients hemoperfusion, the patient atropine and cholinesterase activity of the time the recovery time of patients with other severe poisoning was significantly shorter compared. Severe organophosphorus pesticide poisoning dangerous disease, high mortality, lack of specific treatment for the large amount of poison, poisoning symptoms and, poison for a long time to wash 36O Changchun University of Technology (Natural Science) Volume 28 of the stomach is not complete, but with who have respiratory and circulatory failure in the conventional medical treatment, based on those conditions should be applied as soon as the blood perfusion. Complications: a pro-nerve poison organic phosphorus can be directly caused by the heart, brain, liver, kidney and other major organ damage, the common cause of death was respiratory failure and cardiac arrest occurred in the AOPP rebound acute phase or when The more the central respiratory failure, in sufficient quantities, while atropine, combined with the right amount of respiratory stimulants. Symptoms of acute poisoning, respiratory paralysis and limb proximal muscle weakness, etc., are indications for the peripheral respiratory failure, IMS should be alert to occur. Therefore, in the rescue process, the fluid can be given according to the disease, correcting water, electrolyte, acid-base disorders, to prevent cerebral edema, antibiotics, if necessary, transportation of fresh blood and other comprehensive treatment to prevent complications. In addition, vital signs should be closely observed, early detection of condition changes, and timely treatment is the key to successful treatment.