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Received 9 one percent 21) (Yue Jing brick edit) urapidil on left ventricular function in patients with old myocardial infarction term effects of Sun Wen-Tsai Wang Xi LEARNED column Dong Daquan Electric treatment of Cr (Tangshan Tangshan,[link widoczny dla zalogowanych], Hebei Province People's Hospital 063 001) Key words carry Ukraine cardiac function in myocardial infarction in Seoul Chinese porcelain Gan Lou law credentials DOI R972. e risk of myocardial infarction complicated by heart failure clinical prognosis is poor and high mortality. For these patients how to improve the Code function. I improve the survival rate of clinical concern. The purpose of this study can improve observation of urapidil in patients with old myocardial infarction left ventricular function. 1 1.1 objects and methods the object side of old myocardial infarction 16 (OMD, concurrent left ventricular heart function by expanding the event were enrolled in this study. M 9 side,[link widoczny dla zalogowanych], woman 7 down, the average age (55.4 = 4. Cool

years. All patients met: ① a history of MI. electrocardiographic myocardial infarction graphics (abnormal Q waves), echocardiography confirmed the corresponding infarct regional wall motion disorders; ② from the echocardiographic left ventricular size, diastolic diameter male ≥ 55mm, female ≥ 50mm, the left ventricular expansion; @ left ventricular dysfunction, such as exertional dyspnea, paroxysmal nocturnal dyspnea and pulmonary edema, echocardiography, left ventricular ejection fraction (and research) ,[link widoczny dla zalogowanych], left ventricular fractional shortening (Fs) <35; ④ echocardiography, left ventricular enlargement caused by other than sputum by patients in New York Heart Association (NYHA) criteria. cardiac function grade 2 inverted Ⅱ, Ⅲ grade 8 sides. Ⅳ down 1.2, 6 patients were administered method of application of this group of urapidil (also known as Urapidil E_branti [), initial doses were Regardless 25rn ~, diluted in normal saline in the intravenous injection of lOml, maintenance dose adding 25ml normal saline intravenously 50mg 2h, 4fig / (kg · rain), treatment 1 ~ 7d If high blood pressure can be increased dosages of discretionary {Youth and speed. with boron addition on the basis of treatment, ask not the same apply the other blood vessels to expand Jing or antihypertensive drugs. 1.3 markedly effective hand-set ①: Ⅱ level to improve cardiac function or cardiac index (cI) compared Increased .0 L / (Ⅻ n · m), @ an effective improvement of cardiac function or c1 higher than before the treatment ho 0.5L / (n ~ n ·); ③ invalid: does not meet the standards of effective treatment. Simultaneous determination before and after treatment of blood pressure, heart rate, systolic blood pressure and heart rate changes and Application of dual-product of the U.S. Hewlett-Packard 2500 ultrasound scanner i set the parameters of left ventricular function before and after treatment change. 2 Results of clinical observation showed that after treatment the patients had clinical symptoms and signs improved in different degrees, of which 8 cases were markedly effective (50), effective in 6 cases (37.5). invalid 2 inverted (I2, 5), 87.5. application Siniora to later heart failure patients significantly reduced systolic blood pressure, Shu Yu pressure, heart rate and systolic blood pressure heart rate product value. together with changes in left ventricular function parameters in Table 1. 3 side of the course of treatment in patients with mild nausea and dizziness. Zhu see other adverse reactions. Table 1, blood pressure, bearing in mind that the left ventricular function parameters (n a 16i persons) 3 discussions piperazine urapidil benzene substituted uracil derivatives Piao with the dual peripheral and central mechanism of action. the role of peripheral vascular relaxation of the tongue adjacent the main block of synaptic receptors. the peripheral resistance decreased significantly, but also a moderate contraction of blood vessels blocking effect of catecholamines (which is different from the piperazine azole hydrochloride and peripheral nerve); central role mainly through the activation of 5-HT 1A receptors. reduce the medullary sympathetic cardiovascular center section of the sky that the antihypertensive effect of feedback (which is different from the pivotal role of clonidine.) 』caused by animal experiments, body studies have confirmed that a good antihypertensive effect and tolerability, and no effect on metabolism. heart failure patients with Siniora and later can be beneficial to the hemodynamic effects of left ventricular end diastolic pressure, systemic vascular resistance and pulmonary artery pressure, pulmonary capillary wedge pressure decreased significantly, while cardiac index and stroke index increased significantly after treatment in this group of patients the clinical symptoms and signs are mostly improved significantly, heart rate, blood pressure and heart rate, double product of systolic blood pressure decreased significantly, and CVEF, LVPFR obvious increase of urapidil on myocardial infarction heart failure, can the pulse blood flow, heart rate, systolic blood pressure combined with the treatment of tongue double product decreased, reflecting the reduction of myocardial oxygen consumption. beneficial, myocardial protection, suggesting the drug on the sympathetic nervous Antagonism of such patients is very beneficial. This group of only 3 down dizziness, nausea and other side effects, but mild symptoms can be tolerated, did not affect the further treatment. in all cases there is a degree of blood pressure and soon reach the limit stabilization levels shows that urapidil can be used not only to control blood pressure, can also be safe and effective in patients with old myocardial infarction improved left ventricular function. (1999, Rights issued a O7O1) (Li Qingyou edit)
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