e707004304
ORANGE EKSTRAKLASA
Dołączył: 17 Gru 2010
Posty: 612
Przeczytał: 0 tematów
Ostrzeżeń: 0/5 Skąd: England
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Wysłany: Nie 1:08, 27 Lut 2011 |
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Lamb fattening Chinese herbal compound preparation of granule
Ultrasonic temperature 35 ~ C lh centrifugation supernatant, measured absorbance values, and calculate the content of magnolol. 2.4.3 Determination of water amount to take the test, tiled drying to constant weight in the flat, said the bottle,[link widoczny dla zalogowanych], the thickness of no more than 5mm, loose offerings of not more than 10mm, precision set, open the bottle in the 100 ~ C drying 5h , the cap cover, removal dryer, cooling 30min, precision set weight, and then dried in the temperature lh, cooled, weighed, the difference between two consecutive weighing far less than 5mg. According to the weight loss was calculated for the test materials in water content (%). 2.4.4 Test check size amount of granules,[link widoczny dla zalogowanych], said that given the weight of home drug screening sieve. Screening, it will remain horizontal screen, moving around from screen gently 3min. Can not 一号 screen and sieve through 四号 the sum of particles and powders may not be over 10.0%. 2.4.5 Test check granules dissolve 1.50g, plus extra 80 ~ C hot water, stirring 5min, immediately observed. Almost all the granules dissolve, and only slightly cloudy. 2.4.6pH value test of the above mentioned granules melted liquid, with the pH meter test pH. 3 Results 3.1 Single cream powder materials and the compatibility of dry powder moisture percentage rate and the measured results shown in Table 1 and 2. Table 1 The single materials and dry cream powder and powder compatibility rate of prescription of Table 2 materials with a single cream powder dry grain moisture percentage of the compatibility of the system t / h water absorption (%) t / h water absorption (%) 42.64l85.5O83. 1O245.8Ol24.62 percentage moisture absorption by the fine rate and the results can be seen, one with powdered sugar for its fine materials remains high, and difficult to maintain the original shape when grain moisture, while the liquid-like, so consider the added species on the hygroscopic drugs have a stabilizing effect and easy to balance the water and sugar together granulating materials, considering the choice of the dextrin, and its dosage were selected. Figure 1 single-particle absorption rate of the prepared materials 3.2 cream powder, two kinds of materials compatible with the dry powder after the determination of rate and moisture percentages shown in Table 3 to 4. Table 3 two materials with dry cream powder and powder compatibility rate of prescription of two materials in Table 4 compatibility with the dry extract powder particles of the moisture percentage of 5004.00 made good 3. O0 din 2O01O00.00f / h Figure 2, the system of two particles of the moisture absorption rate of materials from the results can be seen from both fine rates and water uptake of view,[link widoczny dla zalogowanych], should be dry paste powder: sugar: dextrin = 3:2 : 1 ratio is better, so dextrin powder instead of powdered sugar can reduce the rate, while the particles can be maintained after the grain moisture. 3.3 The choice of wetting agent results in Table 5. Table 5 Particle preparation conditions and the relationship between ethanol concentration of ethanol concentration (%) to prepare pellet case 405O60708090 easy, easy to gather particles National Cheng Kung University,[link widoczny dla zalogowanych], powder more difficult to pellet hard particles, hard particles, powder and more granulation in general, less good granulation powder, powder less, moderate amount of granulation good wetting agent, fine less the amount of large granulation good wetting agent, fine powder less, a large amount of wetting agent from the Table 5 into account, when the pellet hardness of soft materials and the concentration of ethanol is directly related to moisture absorption from the fine rate and the choice into account the concentration of wetting agent is 70%. 3.4 index test results in table 6. Table 6 Indicators granules by granulation test 4 conclusions (extract powders, type and amount of materials selection, the choice of wetting agent) ratio of the different aspects of the use of materials and experimental conditions selected from the fine rate and absorption rate Considering the final preparations to determine the granulation methods are: dry cream powder: sugar: dextrin ratio = 3:2:1 mix evenly, a modest 70% ethanol as wetting agent made of soft material, head over l8 screen made of particles, over l4 mesh whole,[link widoczny dla zalogowanych], 80 ~ C drying derived. The method is simple and easy.
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