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ORANGE EKSTRAKLASA
Dołączył: 26 Paź 2010
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Wysłany: Nie 9:32, 06 Mar 2011 |
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Patients with myocardial infarction myoglobin Clinical significance
Disease mortality and morbidity is extremely important. The myoglobin is now elevated myocardial infarction in the earliest biochemical indicators, the determination of myoglobin in early diagnosis and treatment monitoring of myocardial infarction have a certain value. 1 Data sources and methods 1.1 specimen samples 4O hospital diagnosed cases of hospitalized patients, healthy control group 2O cases. 1.2 Instruments and reagents myoglobin was determined by immunoturbidimetric method, apparatus, one of Japan's TBA 40FR. Leadman reagents provided by the measured parameters provided by the kit, reference range of O ~ 85ng/ml. 2 results in hospitalized patients 4O clinically diagnosed cases,[link widoczny dla zalogowanych], 34 cases were first admission myoglobin also increased> 1DOng/ml,[link widoczny dla zalogowanych], along with the development of the disease and thrombolytic therapy, the results gradually increased and then decreased to reach a peak . 6 patients had just taken admission myoglobin in serum samples of the result is normal, then the 1 ~ 3h after the specimens were collected, began to increase myoglobin found in healthy control group 2O cases were normal. 3 Discussion myoglobin molecular weight of 17.5kD, is a 153 amino acid polypeptide chain and a ferrous heme protein composed of heme, present in skeletal and cardiac muscle and other tissues. Because myoglobin molecular weight is small, can quickly myocardium from ischemia rapidly released into the blood after myocardial infarction in 1 ~ 3h rapid rise in blood levels, 6 ~ 7h peak,[link widoczny dla zalogowanych], 12h lipids in diabetic patients unusual treat nearly all patients with myocardial infarction myoglobin has increased, rising by a big margin. And because of the short half-life of myoglobin, only 15min, 6 ~ 12h after the onset of chest pain does not increase can be ruled out myocardial infarction, is also a good indicator other than myocardial infarction. Myoglobin is cleared from the kidney in the pathogenesis of l8 ~ 30h can be fully restored to within normal levels. Therefore,[link widoczny dla zalogowanych], myoglobin would help determine the course of myocardial infarction observed with or without re-infarction or infarction extension. Myocardial infarction of elevated serum myoglobin and the magnitude and duration of infarct size and myocardial necrosis was positively related to general and extensive subendocardial infarction, serum myoglobin increased sustainable 3 ~ 4d. If the serum myoglobin did not fall or sustained increase or decrease but increase after abnormal, indicating continued expansion of infarction, myocardial necrosis increased or new infarction. However, because myoglobin is also present in skeletal muscle and other tissues, muscle damage will increase, so to be judged or clinical. Because myoglobin diagnostic sensitivity and specificity of myocardial infarction, or high, so the early determination of myoglobin for early diagnosis of myocardial infarction has some reference value.
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