Nasal drug treatment for clinical trials of headac

e707004304 · Wysłany: Czw 19:50, 24 Mar 2011

Nasal drug treatment for clinical trials of headache

Medicine approach, after oral administration, drugs before entering the circulation from degradation, including degradation and metabolism of the gastrointestinal tract and liver first pass effect,[link widoczny dla zalogowanych], etc., these factors lead to reduced bioavailability of drugs. Nasal administration of drugs without a direct role in the gastrointestinal tract and the site, a small amount of drugs that reach the higher plasma concentration, generally only oral dose of 1 / 10 or 1 / 15 or so. Thereby decrease the side effects of drugs ..., is to enhance bioavailability, and avoid drug-induced gastrointestinal side effects, reducing the load on the liver to drug metabolism and drug adverse effects on the liver. Human nasal surface area of 150cm, mucosal surface epithelial cells have many microvilli, increase the effective area of drug absorption, and lower nasal epithelium is rich in capillaries and lymphatic vessels,[link widoczny dla zalogowanych], enabling rapid absorption of drug into the circulation. Nasal blood circulation and blood circulation of the brain are closely interlinked, there is a potential between the nose and skull and direct micro-channels. Nose and a very close relationship between cerebrospinal fluid, studies show that dopamine, nerve growth factor, administered through the nasal cavity directly into the cerebrospinal fluid. Part of the nasal cavity is the skull, there are many small holes, like a nasal endothelial cribriform plate, nerve bundle through this hole, filled with cerebrospinal fluid around, so drugs can be passed in cerebrospinal fluid after nasal instillation. Practice has proved that cephalexin, fluorouracil and other nasal administration of the drug concentration in cerebrospinal fluid after injection of higher than .... Therefore,[link widoczny dla zalogowanych], treatment of brain diseases, nasal administration has a unique advantage. Some of gentamicin sulfate with polar compounds as a research medium of nasal absorption of drugs bioavailability,[link widoczny dla zalogowanych], 10 dogs at 5mg/kg to use vein, muscle, and nasal administration of three ways, through the thin layer chromatographic scanning method 0,10,30,60,120,180 min after administration of gentamicin sulfate in serum concentrations of drugs found in the nasal mucosa after 10-30min, peak serum gentamicin is administered intravenously to 70. 1%,[link widoczny dla zalogowanych], intramuscular injection, 1_55 times the bioavailability of intranasal route of administration of up to 80.5%: The intramuscular injection of only 42% n. The nasal absorption of drugs may have varying degrees of nasal injury or stimulation, studies show that this damage is reversible, in our clinical studies, did not find any side effects. And the time from the onset, nasal administration is superior to oral administration. 4 Conclusion The rapid onset of nasal drug delivery, absorption completely, to avoid first-pass effect of oral drugs, bioavailability, convenient administration, a small dosage, side effects. Treatment of nasal administration headache is a unique advantage of the delivery method.