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yxfbbiedtj · Wysłany: Śro 4:04, 09 Mar 2011

Elderly stroke patients with acute C-reactive protein tumor necrosis factor and interleukin-6 Level

Important role. We in February 2002 to March 2005 140 cases of stroke were selected by ELISA method to measure sensitivity C-reactive protein (hs-CRP), measured by radioimmunoassay of tumor necrosis factor-a (TN ~ a), interleukin 6 (IL a 6) content,[link widoczny dla zalogowanych], are reported below. First, the object and methods 1. Target: cerebral hemorrhage and 140 cases of hospitalized patients with cerebral infarction, aged 60 to 76 years, mean (69.0 ± 10.4) years old, 72 cases of cerebral hemorrhage,[link widoczny dla zalogowanych], cerebral infarction in 68 patients; healthy as the control serum of 60 patients group, aged 60 to 70 years, mean (65.0 ± 6. Cool

years. All cases were within 24h disease, diagnosis in 1995 the fourth meeting of cerebrovascular disease diagnostic criteria established by mouth], and within 3 days of admission by head CT or MRI examination confirmed. All subjects had no acute or chronic infections, and other than cancer,[link widoczny dla zalogowanych], recent surgery or trauma, chronic connective tissue disease and heart valve disease and other medical history. hs-CRP kit from last Haibei Xi Limited, TNF-a, IL a 6 from Beijing kit Tektronix biological bonding companies. 2. METHODS: Patients were collected on day after admission 1,3,7,15 cubital vein 4ml (control group, while blood sampling) in a regular test tube, 3000r/min centrifugal 10min, the serum taken after the upper switch to eppendorf tubes,[link widoczny dla zalogowanych], a 20 ℃ refrigerator , measured within 1 month, using ELISA method to measure hs-CRP, measured by radioimmunoassay TNF-a, IL a 6 content. 3. Statistical analysis: application SPSS10.0 statistical software for data analysis, data ± s said. Second, the result of cerebral hemorrhage and cerebral infarction serum hs-CRP, TNF-a and IL-6 content in change: the content of the first 1,3,7,15 days compared with the control group in Table 1. Cerebral hemorrhage and cerebral infarction group hs-CRP, TNF-a, IL a 6 in the same time the three-phase correlation between the two found in the early (first 1,3 days) twenty-two was a positive correlation (r A 0.53,[link widoczny dla zalogowanych], P O.05). Table 1 elderly stroke patients with hs-CRP, TNF-~ and the dynamic changes of IL-6 levels (s) the number of cases trainer foot Note: cerebral hemorrhage and cerebral infarction group, P <O. O1 of the discussions recent study found that changes in the vascular wall involves a cascade of inflammatory process, inflammation with macrophages, the production of cytokines, complement activation of pro-inflammatory media directly involved. Cerebral infarction aggregation and infiltration of leukocytes, the inflammatory process affecting the extent of the injury. Inflammatory process also exists cerebral hemorrhage. TNF_a can cause the secretion of other factors such as the release of IL-6, these factors of inflammation in the body start, maintain and play an important role in the regression. TNF-a is a key mediator of inflammation. Acute intracerebral hemorrhage in patients with cerebral infarction group and 1,3 days after the first three levels were high, old cerebral hemorrhage group and the incidence of cerebral infarction on day 1, day 3 the highest, tends to restore the 7th day, and time match. 15 days turnaround trend, the three serum levels were gradually decreased, but still higher. There is a cause of cerebral hemorrhage, cerebral infarction is still recovering from the three reasons for the high serum levels.