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yxfbbiedtj · Wysłany: Wto 10:21, 15 Mar 2011

Drug Intermediates 7 - Preparation of acid aminocephalosporanic

70min sampling to determine when the reactions with acetic acid buffer, 2 Tianjin Pharmaceutical TianjinPharmacy2005 the first month of l2 l7 No. 6 (pH = 3.5) for high performance liquid chromatography. After the reaction, the material immediately into the next reactor. 1.2.2GL a 7 a 7 a ACA ACA into the reactor above, using a funnel off to join the immobilized GL acyl enzyme 5KU,[link widoczny dla zalogowanych], 1000n1l repeatedly washed with deionized water 3 times within the reactor through N2 is sterile adding the above reaction mixture, mixing temperature, pH controller through the hydrogenation of ammonium oxidation, maintain pH constant, 0,20,40 and 60min, the reaction sample,[link widoczny dla zalogowanych], the same liquid chromatography analysis to determine the reactions. ACA 7 further crystallization of a reaction and dry,[link widoczny dla zalogowanych], made into powder. HNMR, m, FAB-MS confirmed structure. Reaction shown in Figure 1. C00H cephalosporin intermediate pension GL. 7. ACACO0H product of Figure 1 Preparation of 7-ACA 7. The reaction ACA 1.3 Technical Index Appearance White or almost white crystalline powder Assay> 98% moisture content of 98%, the indicators meet the requirements, product quality is good. Because the use of CPC solution as raw material, chemical lysis method without complex, expensive reagents,[link widoczny dla zalogowanych], so the cost of appropriate and harmless to human body, technology is simple,[link widoczny dla zalogowanych], homemade enzyme preparation on an ACA 7 has important practical significance.