Zinc inhibition of the central nervous system NMDA

e707004304 · Wysłany: Czw 0:20, 03 Mar 2011

Zinc inhibition of the central nervous system mechanisms of NMDA receptor responses

anIX, ZukinllS. Developmentalle ∞ and ∞-11-8peci ~ cexpre ~ ion0fN-methyl'Da. ~ 'TatcI't ~ ptOrsplicevariantsinrathi ~ [J]. Neuro ~ i ,1997,79:399-409 .10 Burgess. P (, w ∞ s'L. TraynelisNF.Asparagine616intheNmsuburfitcontrolspermineblock,[link widoczny dla zalogowanych], spenr ~ nepotentiation, andpH9msitd) [J]. SoeNeuro ~ iAl ~ tr, 1996,22:588.11 r. ~ WagiK. PshkAj, SlK ~ lkoT, eta1. BlockandModulation0fN-IIle. thylD-~ partatel'eC ~ Ol'8by ~ y. mi. eandprotons: role0fltllTlinoacidresidue ~ inthem female meIl the Ia】 rIeandf_ ah ngT0lls0fNR1andNR2suixmits [j]. 1 ~ 1olPhannecol,[link widoczny dla zalogowanych], 1997,52 (4) :701-713 .12 sea, ~ PH, SingleF,[link widoczny dla zalogowanych], Kllnel Cenetie 【plllaii0n0fkeyde-ternfmants0fionflowinO-t. r ~ I't ~ ptOl ouse [J]. BrainRes. 2001,907:233-243.13 XiongZG. PelkeyKA, KuwY, eta /. Stcpot ~ tiation [JJ0fNMDAre-eepto ~ sinhippoean ~ andspinalneIlr0tlsisnotmediatedbyreducingzincinhibition. JNeurosci ,[link widoczny dla zalogowanych],1999,19:5889-5897 .14 BelgerML. RebernikP. ZincandifenprodilaUostericallyinhibittwoselratepolyan ~ ne-semitivesitesatN-methyl'Da. ~ 'Tatel ~ optolrc0lTI-p1 [J]. JPET ,1999,289:1584-1591. * SMS 08G protein-coupled PI3Kr mast cell function in the central role of Laffarque found (August2OO2), a phosphoinositide-3 kinase A 7 () increased responsiveness of mast cells play a central role. He used the lack of PII (r enzymes to do the bone marrow mast cells in vitro, and found that cells of IgE stimulation of a complex antigen, can not lead normal degranulation reaction, the reaction is much lower than the wild-type mast cells ,[link widoczny dla zalogowanych], indicating that the activation of mast cells in adenosine PI3Kr the signal conversion chain is necessary for a link. Another is the use of in vitro adenosine receptor antagonist, found that increased bone marrow mast cell reaction glycosides and A3 receptor gland 533, and A3 adenosine receptor activation via trimeric G protein I (r, generating PI (3,4.5) I) 3 the latter is caused by the release of granules containing histamine, further evidence of the role of PI3Kr. He's another body Experimental results show that the lack of PI3I (r mice injected with adenosine without the formation of edema. The in vivo experiments show that the process of GPCR signaling, mast cells for enhanced antigen on IgE reactivity of a, PI3I (r is a necessary essential part. (Su Tao Cheng Guansheng) 09PKC a 6-deficient rat B cell proliferation and enhance their immune response in the PKC isoforms, only PKC overexpression of a 6 can inhibit cell growth. study ( Nature ,2002,416:865-869), the thorn case, PKC.6 lack of amplification of rat B lymphocyte population was significantly increased. and B cell proliferation on stimulation