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yxfbbiedtj · Wysłany: Pią 15:54, 11 Mar 2011

Adriamycin decalcified bone matrix particles Preparation of bone cement and in vivo release test release

Slow release of sustained and relatively stable, the results show that the sustained release of doxorubicin release fitness over 12 weeks, early release at high concentrations, and then released at low concentration and stability. Doxorubicin concentration in plasma drug tablets in 10min after implantation occurs, 24h to reach the peak, a very low level heaven 2, 1 Zhou Houji the disappeared. B in plasma after intravenous injection of adriamycin appeared in, 6h was significantly decreased to 36h disappeared. Sustained-release implant in rabbits, the local high drug concentration in bone, plasma drug concentration is low, the unit dose and total dose of basically the same case, the drug particles in the plasma group and the injection group in the highest concentration of doxorubicin ratio of 1:10, while the highest concentration of adriamycin bone ratio of 29:1. Thus, adriamycin DI) S can repair bone defects after tumor operation, but also make a short time the release of doxorubicin and high dose to maintain a certain amount of time, can play a partial inhibition to kill residual tumor cells. BC in the polymerization process can produce high temperature, is generally believed that mixing drugs should be selected BC-resistant and water-soluble polymerization good powder drugs. BC made a variety of common units currently the highest temperature measured was 63 ~ 71 ℃, and the research shows that], the temperature by its own volume fraction, spatial geometry and the surrounding environment and other factors. Reported], doxorubicin 6O ℃ when the inhibition rate of tumor cells is not affected, 100 ℃ when the inhibition rate decreased 4. Yong will DBMP by 300rag/kg such a mass ratio, and BC composite, the composite material element determination of the maximum temperature is 51.3 ~ C; by 400rag/kg quality than with the BC compound, the unit is lower than the maximum temperature of 5O ℃; composite higher clay content in the bone material, Bc lower the temperature of polymerization and generate heat easily disseminated. Therefore, the sustained-release system produced during the preparation of doxorubicin temperatures below the temperature limits of physical and chemical properties, has the value of doxorubicin mixed. Currently, bone tumors after topical application of the value of chemotherapy drugs have been sure, but mostly in the form of topical chemotherapy or gelatin sponge, the direct application of the local application of absorption, rapid drug absorption of these drugs way, it is impossible to maintain in the local longer effective concentration, and thus less than ideal results. Chemotherapy because the tumor while meeting short time to be a large amount of dose and time of the dual requirements of maintaining, therefore, an ideal bone tumors after local topical dosage should be chosen large, long duration, low concentration and systemic blood sustained-release formulations of small side. DDS both doxorubicin and good integration of bone tissue repair of bone defects, but also in the suppression of local continuous release of doxorubicin to kill residual tumor cells, prevention of local recurrence is expected to limb salvage in the treatment of bone tumors play a positive role.