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Lipo United methylcobalamin on diabetic peripheral neuropathy efficacy

Chinese papers League finishing. Of: Guojie Xia,[link widoczny dla zalogowanych], Yi Yun Su, cable from the British Key words diabetic peripheral neuropathy; methylcobalamin; Lipo [Abstract] Purpose Cake when combined with methylcobalamin on diabetic peripheral neuropathy. Methods 120 patients with diabetic peripheral neuropathy were randomly divided into control group and treatment group, control group 60 cases,[link widoczny dla zalogowanych], a single intramuscular injection with methylcobalamin daily 500μg, 4 weeks; treatment group, 60 patients in the control group based on the increase 10μg alprostadil plus 1 day in 100ml normal saline intravenous for 4 weeks. Results 96.7% effective rate in treatment group was significantly higher than 48.3% (P [Keyword] diabetic peripheral neuropathy; methylcobalamin; Kaishi diabetic peripheral neuropathy (DPN) is a common chronic complication of diabetes , clinical symptoms with persistent pain, numbness and impaired sensation for the performance, bringing great suffering to patients, but there is still a significant lack of efficacy of treatment [1]. Because the pathogenesis of diabetic peripheral neuropathy complicated, to participate in a variety of pathological factors, role in several aspects [2], which for some pathological aspects of the clinical efficacy of single agent can not be achieved satisfactorily. When our hospital Kay United methylcobalamin on diabetic peripheral neuropathy, the clinical results were satisfactory, are summarized below. 1 Materials and Methods 1.1 General Information Select December 2003 ~ December 2005 patients in our hospital and 120 patients were diagnosed patients with type 2 diabetes (according to 1997 ADA diabetes diagnostic criteria), accompanied by the following four symptoms: (1) limb paresthesia: numbness, pain and other sensory abnormalities; (2) decreased with the knee jerk reflex; (3) limb MNCV (motor nerve conduction velocity), SNCV (sensory nerve conduction velocity) conduction velocity; (4) to exclude other causes of peripheral neuropathy. The patients were randomly divided into two groups, treatment group 60 cases, 32 males and 28 females, aged 49 to 92 years of age, duration of 8 to 27 years. Control group, 60 patients, 33 males and 27 females, aged 50 to 79 years, duration of 9 to 26 years, the two groups were comparable. 1.2 Methods All patients were given scientific exercise,[link widoczny dla zalogowanych], diet control, lowering blood sugar comprehensive treatment, when blood sugar control standard in the control group was given added methylcobalamin 500μg intramuscularly, 1 day, for 4 weeks; treatment group was given methylcobalamin 500μg intramuscularly, 1 day, while Jiakai 10μg when added to normal saline intravenous 100ml 1 day for 4 weeks. All patients before treatment and after treatment in the early morning fasting blood glucose test, blood biochemistry, liver and kidney function, blood routine,[link widoczny dla zalogowanych], record symptoms (numbness, pain, paresthesia) and signs (tendon reflexes, depth of reflection), measured nerve conduction velocity and blood pressure. 1.3 markedly efficacy criteria: significant improvement in symptoms, with significant improvement in the knee tendon reflex, rehabilitation, or the depth of feeling completely back to normal. Possible increase in nerve conduction 5m / s or more, or back to normal. Effective: symptoms improved, with improved knee tendon reflexes, depth of feeling improved, nerve conduction is less than the previous increase of 5m / s; invalid: No alleviate the symptoms, tendon reflexes, depth of feeling no improvement over the previous non-nerve conduction change. 1.4 statistical methods to count data rate between the groups (%) said measurement data with mean ± standard deviation (x ± s) said, using t test. Application of SPSS software for statistical analysis. 2 results 2.1 Clinical Comparison of the two groups treated group than the control group, the difference was significant (P <0.01), see Table 1 . Before and after treatment fasting blood glucose, 2h postprandial blood glucose, liver function, kidney function did not change significantly in both groups no adverse reactions.