_8847 On rational use of antibiotics

ncycgdxhl · Wysłany: Czw 15:34, 03 Mar 2011

Rational use of antibiotics

Bacteria are to continue breeding, and breeding of bacteria, the 8-short half-life of a lactam antibiotics, blood or tissue concentration of bactericidal antibiotics fail, resulting in an effective antibiotic is not playing its due effect. Therefore, the use of such antibiotics should be based on claims of drug half-life, anti-bacterial blood concentration and duration of the effective length, to determine the drug delivery via, dosage and method. 2, the basic principles of rational use of antibiotics rational use of antibiotics, patients required a comprehensive understanding of clinicians, pathogens and the basic situation of the three antibiotics, 22l5 and to explain the relationship between the three, in which patients with minimal risk, maximum treatment. First, the basic principle of the use of antibiotics is safe and effective, and safe and effective is the key to rational use of antibiotics. Effective is the premise, because the infection under control as quickly, the antibiotic treatment is not too long,[link widoczny dla zalogowanych], because of adverse drug reactions and long-term use of antibiotics may be caused by double infection and other factors will prevent or reduce unsafe. Second, we should select highly targeted, good sensitivity to antibiotics, the infection was controlled in time, would not have happened due to the escalation of the infection was unable to control the deteriorating course of treatment will be shortened. 3 rational use of antibiotics effective method of infection of 3.1 according to their sensitivity to the pathogen and drug selection. Species of pathogenic bacteria and their sensitivity to certain antibiotics should be analyzed, in particular, microbial diagnosis and antimicrobial susceptibility of clinical trial results have not been clear, competent physicians predilection site of various pathogenic bacteria, clinical presentation, sensitivity and resistance to antibiotics and so should understand in order to draw the basic right to judge and deal with. For example, acute respiratory infections, including acute exacerbation of chronic infections, mostly G pathogenic bacteria, long-term use of antibiotics or immunosuppressive agents in-patients with secondary pulmonary infection, which are mostly pathogens of nosocomial infections resistant to G bacteria, resistance to Golden Grape or multiple drug resistant Staphylococcus epidermidis. 3.2 Analysis of the development pattern of infection diseases and the relationship between the underlying disease. Disorders of various infections has its own law of development of infection was invalid because the original drug treatment, then drugs should be replaced, if not for the treatment of disease control should be effective and retain their effective drugs to continue treatment. Without complication, based on disease status, the choice of antibiotics and development of treatment programs also have a great relationship, such as diabetes, sepsis based on the merger, you need a good analysis of the situation was diabetic infection, when infected the development of sepsis, regardless of how the disease was diabetes mellitus, should be the main contradiction in sepsis, aggressive treatment of sepsis, taking into account the treatment of diabetes. 3.3 Familiar with antibiotics and pharmacological effects of antimicrobial characteristics. To a reasonable choice of antibiotics, antibiotics must be familiar with the classification, mechanism of action,[link widoczny dla zalogowanych], antibacterial spectrum, clinical pharmacological characteristics, indications, contraindications, bacterial resistance, adverse reactions and preparations, dosage, administration via other content. Otherwise, it will make no reasonable treatment. In recent years, various types of antibiotic research progress at home and abroad, the role of old and new varieties must have some understanding such differences, but also a better grasp of antibiotics, clinical microbiology, the basics of clinical pharmacology, the only way to do rational use of antibiotics. Levofloxacin in the treatment of urinary tract infection in 32 patients in Fukang City, Xinjiang Center for Disease Control and Prevention (831500】 sand by the late 80's Rush Ofloxacin is widely used in clinical research and development of one of fluoroquinolones with broad antibacterial spectrum,[link widoczny dla zalogowanych], strong antibacterial activity,[link widoczny dla zalogowanych], easy to use, to prevent the occurrence of renal failure and development of great significance. I in 2001-2005 with levofloxacin treatment of urinary tract infection in 32 cases, the effect is satisfactory. are reported as follows: 1 Data and methods 1.1 Case Selection 32 patients were outpatients, of which 9 males and 23 females, aged 21-52 years. 1.2 treatment 200rag levofloxacin intravenous injection, once daily, cefotaxime injection oxime sodium 2.Og intravenously once daily, a course of 3-7 days, not all cases during treatment with other antimicrobial agents. 1.3 observed signs of adverse reactions observed items in the 24h before treatment and after treatment 1 72h hematuria of the inspection routine,[link widoczny dla zalogowanych], liver and renal function. 1.4 efficacy evaluation (1) cure: treatment of urinary tract infection symptoms and signs disappeared, urine, blood were normal. (2) markedly effective: After treatment, symptoms and significantly reduce the signs, urine white blood cell count decreased. (3) invalid: signs and symptoms after treatment