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yxfbbiedtj · Wysłany: Nie 20:15, 20 Mar 2011

Intravenous infusion of 2 cases of adverse reactions of vitamin K1

1277. [4] AlbertKGmm. Diabetesandsurggry [J]. Anesthesiology, 1991.72 (11): 209 (paper Editor: Zhao Hanying) * intravenous vitamin K1 clinical adverse reactions reported 2 cases of Lu Min (People's Hospital of Yiyang City, Hunan Province of Pediatrics,[link widoczny dla zalogowanych], Yiyang 413001) CLC number: R977. 26; R985; R969 Document code: B Article ID: 1812.7851 (2007) 11-0974.01 Key words: Vitamin K. ; Adverse reactions of vitamin K. Is a commonly used clinical hemostatic,[link widoczny dla zalogowanych], but also has antispasmodic effects, in the pediatric use of more, less allergic reaction occurs, but this year I Division 2 cases of adverse reactions occur continuously, are as follows. 1.1 Case 1 1 Clinical data in children, male, 23d, 2d admitted because of cough shortness of breath. Admission examination: T37 ℃, R50bpm,[link widoczny dla zalogowanych], HR136bpm, Wt4kg, developed normally, the reaction can be. Anterior fontanel was flat and soft, no cyanosis. Coarse breath sounds lungs, smell and wet rales. Heart sound may be, the law together, without noise. Abdomen soft. Limb muscle tone to normal. Term level of production, no asphyxia, breastfeeding. Diagnosis: neonatal pneumonia. Cefoperazone sulbactam resistance to infection and take back suction spray treatment, conventional to vitamin K. 1mg to join Murphy's drip Prevention of newborn hemorrhagic disease management. Vitamin K. After infusion of approximately 3min, noise disturbed children burst into tears, head thrown back, lips cyanosis week, staring eyes, limbs, increased muscle tone. Immediately stop using vitamin K. Be normal saline infusion, dexamethasone 1.5mg bolus, chloral hydrate enema 1.5ml, about 3min or so symptoms. Continue after completion of anti-inflammatory treatment, children with no recurrence of the above, cured and discharged. 1.2 Case 2 children, male, 10mo, 3d admitted to hospital because of cough, wheezing. Admission body check: T37.6 ℃, R38bpm, HR120bpm, Wt8kg, developed normally, Shen Qing, spiritual poor. Anterior fontanel was flat and soft, pharyngeal congestion, no lip cyanosis. Coarse breath sounds lungs, news and more wheezing. Qi rhythm, no murmur. Soft abdomen, liver Youlei under lcm, soft, no palpable spleen, muscle tension normal limbs, past the body and health. Diagnosis: Asthmatic Pneumonia. To cefotaxime sodium, ribavirin anti-infection, theophylline and inhaled asthma treatment, while plus vitamin K. 5mg infusion of Murphy's management to strengthen spasm cough. The infusion of vitamin K. About 4min so, Received date :2007-10-30 Author: Lu Min (1975 a), female, Yiyang,[link widoczny dla zalogowanych], Hunan, undergraduate, degree, attending physician in pediatric clinical work. Children with sudden irritability, crying, head back, pale, lip weeks cyanosis, sweating more. Immediately stop vitamin K. To saline infusion, oxygen, dexamethasone 3mg bolus, 2.5ml enema sedative chloral hydrate. Following the above symptoms after about 6min, children quiet sleep. Continue to be anti-inflammatory and asthma treatment, patient improved and discharged 4d, no other special does not apply in children. 2 discussion of vitamin K. Yellow to orange transparent liquid, light and easy case of decomposition, the fat-soluble vitamins. Coagulation factors in liver II, Ⅶ, Ⅸ, X synthesis, is relatively non-toxic I1. 】. Intravenous injection, there may be facial flushing, sweating, chest tightness and other reactions, can be induced on neonatal hyperbilirubinemia. In recent years, vitamin K. Also beginning to have reported adverse reactions, there can be rash, tachycardia, angina, dyspnea, nausea, severe abdominal pain,[link widoczny dla zalogowanych], anaphylactic shock, convulsions and other performance, adverse reaction mechanism is not clear, it should also be clinically attention, note the following when using the drug in several aspects, as far as possible to avoid serious adverse events: ① asked allergy history of allergy caution; ② Drug treatment should be dark; ③ slower infusion, newborn 5% or 10% glucose diluted infusion 30min or more, intravenous speed of infant or child less than lmg / min, and the total does not exceed 0.8mg / (kg · d): ④ stopped immediately when adverse reactions drugs, and be symptomatic treatment [2,31.