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yxfbbiedtj · Wysłany: Sob 22:43, 12 Mar 2011

New complement inhibitors on renal transplant ischemia reperfusion injury in rats

AnnSurg, 1994,220} 425-432. [3] WeismanI-IFt ~ LFtOWT, LeppoMK, at. Solublehumanc ~ mplementreceptortype1: invlvoinhibitorofcomplementsuppressingpost-ischemiamyocardialinflammationand (ci ro-aJ]. Science, 1990,249 {14B. ['] S ∞ a; ecJY, Borghl-scoazecG, DurandF, £ a1.Complementactlvationafter [schemJa-reperIusioninhumanliverallogralts {incidenceandpathophysiologLaalrde ~ anceEJ3. Gastroentel ~ o [o-gY, 1997,112 {908-918. · 19 · NiculescuF, RusH, ShinMLReceptor-independentactiva-tlonofguaninenucleotide-hindlngregu] atoryp ~ oteirmbytermi-halcomplementcomplexesEJ] JBiolChem, 1994t269 :4417-4423. ForemanKE, VaporciyanAA.BonishBK , eta1.C5ainducedexpressionofP-seLemininendothelialce1 【s [J]. JCllnInvest, i994, 94:1 l47-1155.SmithRAG, 1) oddI, RowlingPJE, etat. CellsurfaceerIgjneetingusingacomp] ementregutatroymoleculemodifiedthasyntheticmyldstoylelectrostaticss ~ dtchderivative-: J3. MolImmunolr1998, 35} 400. DongJ, PrattJR, SmithRAGtetat. App [icationofanovelm ~ hrane-targetedcompl iv tregulatorto [schemia / reperfu-sioninjuryintransplantation. Mollmmunol, 1999,36 I310. D. rIgJrPrattJRtSmithRAG,. Strateesfortargetingcomplementinh / hltorsinischaemLa / reperfusionin) uryEJ]. Mollmmuno 【, 1999, Hong :957-963. Article No. :1005-1139 (2001101-0019-01 aprotinin on the inflammatory response during cardiopulmonary bypass the role of Cao, the Hu Xiaoqin, LI Shao Ran (1. 304 Hospital of PLA, Beijing 100037, China; 2. Fuwai Hospital, Beijing 100037, China) off t feed: Aprotinin red outer loop; inflammatory response in the earnings number: R ~ 54.1 the text ■ code: B1 Materials and Methods down 32 double valve replacement patients, aged 40 to 65 years , ASA grade Ⅱ ~ Ⅲ, were randomly divided into three groups: ① Control group: no aprotinin (n a 6)} ② low dose group: cardiopulmonary bypass (CPB), aprotinin static pump 100 million KIU, pre-charge Xin ranunculus added 100 million KIU, intraoperative continuous infusion 250,000 KIU / h.. until the end of the relevant breast (n Green 13). @ high dose group: CPB aprotinin before the static pump 200 million KIU, Xinjiang filled Canada 200 million people KILl, intraoperative continuous infusion 500,000 KIU / h, until the end of the relevant proline (I 13). application of a uniform surgical, anesthesia, and CPB methods. were before CPB, CPB, after the end of stopping cPB 2