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ORANGE EKSTRAKLASA
Dołączył: 03 Mar 2011
Posty: 720
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Skąd: England
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 Wysłany: Czw 9:32, 17 Mar 2011 |
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Effects of melatonin on carbon tetrachloride liver injury in mice
Compared. 1 Materials and methods 1.1 sl80 mouse tumor model shift Tan t- established tumor lines : Hepatogastr ~ nterdogy, 1996; 4,498 ~ 90511Yu Dun . Ts / nATC, Relter resistance Melatorda: history. blosy ~ thesis. andassaymethodologyIn: Yut-ls. ReiterRJedsMelo ~ onin: biosynthesis, Phy ~ iolgicatEffectsandCHnicalApptlcatio ~,[link widoczny dla zalogowanych], BocaRation: CRCPresslne. 1993; 1 ~ 16Protectiveeffectofmelatoninoncarbontetrachl0ride-inducedoxidativeliverdamageinmiceXUJian-Ming, XUShu-Yun, MEIqiao, DINGChang-Hai, ZHOUAi-Wu (InstituteofClinicalPharmacology, AnhuiMedicalUniversity, Hefei230032) ABSTRACTAIMToinvestigatetheprotectiveef. feetofmelatonin (MT) oncarbontetrachloride (cch) a inducedliverdamageinmice. METHODSMiceweretreatedwithMT (IOrng'kg) atintervalof6hoursa/teradministrationofC Qiu (5rrd, kg a ,[link widoczny dla zalogowanych], ip). Thepreparationofmouselivercellswasper. formedbycollagenaseVlperfusion,[link widoczny dla zalogowanych], andthenthehopat ~ wasincubatedwithCChinthepresenceandabsenceofMT (10 ~ ~ 10-11tool · L I). Theoontentofmalonaldehyde (MDA), aLanineaminotransferase (ALT) andglutathioneperoxidase (GSH-px) activitywereassayedasindicationsofcch. induced1iverdamage. Cel1viabilitywasmeasuredbymeansofMTTmethod. REs1 Ⅱ. TscchinducedsignificantlyhighlevelsofplasmaALTand1iverMDAinmice. CCh. inducedMDAproductionintheliverwasinhibitedbvMTtreatment. buttheelevatedlevelofALTwasnotreducedinmice. Inintrostudy. MTpreventedcsct ~. producedALTreleaseandMDAtormationfromhepatocyt ~ sina (10 a 10 a tool · L a ),[link widoczny dla zalogowanych], andimprovedthecellvia. hility (P <0.05). CONCLUSIONMTconc [er8pro. tectionagainstthedeteriouseffectofOCktomicenv-er, possiblyduetoitsantioxidativecapability. KEYWORDSmelatonin; carbontetrachloride; an. tioxidant; Iiverdamage
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