 Wysłany: Śro 13:03, 02 Mar 2011 Temat postu: Experimental asthma in the lung tissue and vascula |
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| Experimental asthma in the lung tissue and vascular changes of lysophosphatidic acid and dexamethasone inhibited
la1.1ys (iphosphatidicacidasaregu-latorofen (1 (1IhPJjaJ/Jeuk0cy 【einteraetion [JJ. LabInvest ,ghd outlet,1999,79:1227-1235 .110 JPalmetsshoferA,ugg stiefel, RobsonSC.NehlsV.1ysophosphatidicacidaI · a tivatesnuclearfactorkappaBandinducesproin / lammatorygeneexpressioninendothelial (: ells 【J]. ThrnmbHaemost, J999 , 82:】 532 a I537ChangesoflysophosphatidicacidinthelungtissueandplasmaofexperimentalasthmaticratandinhibitoryeffectofdexamethasoneonitWUYun, LIOUXi-cheng (CenterofFibreBronehoseopy,tory burch outlet, BeijingChildrenHospital, Beijing100045,ugg schuhe, China) Abstact: LysophosphatidicacidlevelsOfaasthmaratmodelandtheeffectofdexamethasoneonitwerestudied.TheratasthmaticmodelwasestablishedbysensitizingandchallengingWistarratswithaerosolizedovalbumin (OVA). Ratweredi-videdintoacontrol,mbt scarpe outlet, anasthmaticandadexamethasonetreatmentgroups.Lysophospha ± 78.80) nmol / gwhencomparedwithcontrolgroup (68.94 ± 32.57) nmol / g (P <0.01). Dexamethasonepretreatmentsignificantlyre-ducedLPAlevelinlung (P <0.05). TheLysophosphatidicacidlevelinlungofasthmaticgroupwerecon'elatedwithde-greeofinflammationreflectedineosinophilnumber (P <0.01 ) .TheLysophosphatidicacid / eve / inplasmawasnotsignifi-cantlydifferent.TheresluhssuggestthatLysophosphatidicacidplaysaroleintheoccurrenceofasthma, espesciaallyintheairwayallergy.Keywords: asthma; lysophosphatidicacid; eosinophil |
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