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Clopidogrel non- ST segment elevation acute coronary syndrome

Low molecular weight heparin and aspirin and other applications ,p90x workout calendar, 14d cardiovascular death, myocardial infarction,GHD glätteisen, the incidence of recurrence of angina was still as high as 17.8%, 20%, 15.1% t21,Christian Louboutin Greece, anti-platelet research collaboration ~ (AVTC) meta-analysis suggest that aspirin can reduce cardiovascular death , new myocardial infarction and the risk of recurrent ischemia , but still can not meet the clinical needs [31 , requiring a new treatment to reduce cardiovascular events Dangerous. Aspirin by inhibiting cyclooxygenase , preventing arachidonic acid into prostaglandins and thromboxane A: The way to inhibit platelet aggregation. Ticlopidine play a full role in the anti- platelet drugs to be delayed to after 7 ~ 8d,UGG boots Italia, thereby limiting the drug 's use in acute effects. New thienopyridine derivative clopidogrel is a potent inhibitor of platelet aggregation , 300mg loading dose to achieve steady state after the 2h that anti-platelet effect. The mechanism for the inhibition of ADP -induced platelet membrane glycoprotein Ⅱ b / IIIa fibrinogen receptor binding site exposure. Inducer also caused inhibition of platelet fibrinogen and platelet GPIIb / IIIa receptor binding [ 41, with rapid and sustained antithrombotic effect. This inhibition is specific, does not affect cyclooxygenase or arachidonic acid metabolism. CURE trial showed no ST -segment elevation acute coronary syndrome in patients with clopidogrel and aspirin combination , so that the major cardiovascular events were significantly reduced 20% t51. Our clinical studies have shown that in non- ST segment elevation ACS continued treatment . Composite end point clopidogrel group than in the conventional therapy group , P <0.05, significant difference , and no bleeding tendency , no side effects such as neutropenia . In summary, clopidogrel in reducing non- ST segment elevation acute coronary syndrome in patients with recent (14d1 cardiac event is safe and effective ,belstaff italia, and worthy to be popularized . 【
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