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Wysłany: Sob 7:57, 26 Mar 2011 Temat postu: mbt chaussures paris Batroxobin edaravone combined |
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Batroxobin edaravone combined treatment of progressive cerebral infarction
Restrictions, not more than thrombolytic therapy . DF Di defibrase pod is able to directly degrade fibrinogen in the blood , activating endothelial secretion of endogenous tissue-type plasminogen activator (t-PA), reduce the intensification of the plasma protease inhibitor activity , and enhance Protease active fibers , to thrombolysis , reduce platelet aggregation and adhesion Majesty , so has a lower fiber , thrombolysis, anticoagulation effect of the Air J. After acute cerebral vascular occlusion caused by hypoxic ischemic brain tissue , resulting in ischemia and ischemic center around the penumbra, blood flow can lead to ischemia and reperfusion after ischemia reperfusion injury cascade , including energy Metabolic abnormalities , acidosis,mbt hommes, release of excitatory neurotransmitters , excessive influx of calcium ,Belstaff España, free radical -mediated toxicity. Free radicals which cause brain damage is the direct cause of apoptosis . Thus , scavenging free radicals ,belstaff bolsas, breaking the reaction chain is the basic guarantee of successful treatment . Edaravone is a potent free radical scavengers and antioxidants , can inhibit xanthine oxidase and hypoxanthine oxidase activity and stimulate the formation of prostacyclin cable ,mbt chaussures paris, reducing the generation of inflammatory mediators leukotrienes ,ghd piastra, reduce The concentration of hydroxyl radicals , reducing the development of ischemic penumbra or infarct volume and inhibit delayed neuronal death 【 3]. Edaravone small molecular weight, blood-brain barrier permeability of up to 60 %, after intravenous injection of direct ischemic penumbra to prevent the progress of infarction . In addition, edaravone does not affect blood coagulation , fibrinolysis, platelet aggregation without increasing the risk of bleeding HJ. Takabatake , etc. J, combined with ozagrel edaravone treatment of acute cerebral infarction , showing two drugs than alone can improve the efficacy of edaravone .
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