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Wysłany: Pią 0:11, 18 Mar 2011 |
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ACTH in serum of patients with acute cerebrovascular disease and clinical changes of cortisol
. 05 or P 2oan,[link widoczny dla zalogowanych], their serum ACTH,[link widoczny dla zalogowanych], cortisol levels were elevated with infarct size <20an and the control group significantly (P <0.05) = bad 3 infarction area and ACTH, cortisol between 3 Discussion 3.1 Our results show that acute cerebral vascular down by a disease hypothalamic adrenal axis function abnormal. Serum AC'IT-I, cortisol levels higher in cerebral hemorrhage group was higher than the CI group, is consistent with Olsson reported. The amount of bleeding, the infarct size and serum ACTH, cortisol levels were positively correlated. The amount of bleeding, the infarct size large, ACTH, cortisol levels increased more pronounced. Prognosis is worse. When acute cerebrovascular disease 3.2 ACTH, cortisol causes metabolic abnormalities during acute cerebrovascular disease, ACTH, cortisol increased the reason, we believe that with the hypothalamic-pituitary changes and the pathophysiology of disorders of neurotransmitter regulation factors. When cerebral hemorrhage, cerebral infarction, brain damage, brain edema, intracranial hypertension, or hernia formation, the hypothalamus, pituitary gland produces pathological damage, hypothalamic corticotropin-releasing hormone increased the secretion of pituitary ACTH increase. Adrenal cortex to secrete cortisol increase, which is on the hypothalamus and pituitary feedback inhibition reduced or lost, but also can increase cortisol levels. The neurotransmitter of ACTH, cortisol is a complex process. Research has shown that the cerebral hemorrhage, cerebral infarction, a large number of neural media release from the human synaptic nerve endings and nerve fibers, perivascular to diffuse. Catecholamine agonists, the provision receptor antagonist, 5 same color amines can promote ACTH secretion. Vasopressin may regulate ACTH from the secretion of different ways. Acute cerebrovascular disease, the immune response can also be activated, T lymphocytes produce cytokines which stimulate the secretion of hypothalamic corticotropin-releasing hormone and immune products may also act directly on the adrenal glands to increase cortisol production.
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