e707004304
ORANGE EKSTRAKLASA
Dołączył: 17 Gru 2010
Posty: 612
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Skąd: England
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 Wysłany: Sob 23:38, 19 Mar 2011 |
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Triptolide in human lung adenocarcinoma A549 cell proliferation and apoptosis
thway: theroadstoruin [J]. Cell, 1998; 94:695-86GreenDR, ReedJC. Mitochondriaandapoptpsis [J]. Science, 1998; 281:1309-127LiuQ, ChenT, ChenH, ZhangM, LiN,[link widoczny dla zalogowanych], LuZ, eta /. Trip. tolide (m2490) inducesapoptosisofdendriticeeUsthroushse. quentialp38MAPkinasephosphorylationandcaspase3activa. tion [J]. BiochemBiophysResCommun, 2004; 319:980-68 Li Zhikui, FORCES, Wang Long, Qian Gui-sheng. 11) of asthmatic guinea pigs with different densities and bc/-2mRNA eosinophil expression of apoptosis [J]. International Journal of Respiratory volumes, 2005; 25:161-3,1719 book Gui Zhong, Cheng-based Yan, Huang Jichun, Chen Deyu. Triptolide on guinea pig skin c-fos gene expression and regulation of epidermal regeneration [J]. China l Clinical Rehabilitation,[link widoczny dla zalogowanych], 2OO6; 10:46-7 · 1278 · ChinJClinPharmacolTher2OO6N-ov-; 1_l (1lEffectoftriptolideonproliferationandapoptosisinA549lungcancercellSONGLan,[link widoczny dla zalogowanych], XUZhao.j fan, ZHANGCai-ping, QIAOXin-huiDepartmentofMolecularBiologyandBiochemistry,[link widoczny dla zalogowanych], NanhuaUniversity, Hengyang421001, Hunan, China; c_ardiothoracicSurgeryoftheFirstAffiliatedHospital,[link widoczny dla zalogowanych], HunanUniversityofTraditionalChineseMedicine, Changsha410007 , Hunan, ChinaABS11RACTA: Tostudytheeffectoftriptolideoncellproliferationandapoptosisinhumanlungcancercel1.M mouth Ec1 【10DS: 111eeffectoftriptolideoncellviabili-tyinA549cellwasevaluatedbyMTI'assay. CellapoptosisWasobservedbyflowcytometryandDNAladderanalysis.Activitiesofcaspase .. 9andeaspase .. 3wereassayedwithcaspasecolorimetricassaykit.R Contact: Triptolide (eg. ,0.5-4 .0. ml) inhibitedcellgrowthandin-ducedapoptosisinadose -dependentwayat24hincells.Theactivationofcaspase a 9andcaspase-3Wassig-nificandyincreasedat24hincellswhenexposedtotriptolide (eg. ,0.5-4 .0 ttg'ml). CONCLUSION: TriptolideinducesapoptosisinA549cellspartlythroughmitochondrialsialtransduetionpathway.KEYWORDStriptolide; lungcancer; apoptosis
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