Norvasc treatment of hypertension (22 cases) _1917

e707004304 · Wysłany: Nie 12:40, 20 Mar 2011

Norvasc treatment of hypertension (22 cases)

Change. Total, i wen I supine, right upper arm blood pressure measured once each morning and evening, before taking the treatment after discussion and ECG were done and liver and kidney function. Norvasc is a basic dihydropyridine antihypertensive drugs, therapeutic efficacy markedly: DBP ≥ 1.33kPa, long half-life (35 to 45 hours),[link widoczny dla zalogowanych], a higher bioavailability of Jiangsu Medicine 13 1996 22,[link widoczny dla zalogowanych], No. 4 289 * in degrees (60 ~ 65), the role of slow and sustained, significant rise effects and reduced renal vascular resistance, and plasma renin activity of aldehyde fixation. It inhibits calcium channels by the slow inflow of cardiovascular and catecholamine levels of ketones in this group with no significant effect on network organization, the role of dilation of blood vessels to ease, avoiding the blood concentration of fast living hi 5rag dose. 2 to 3 days after taking the blood pressure has decreased speed changes, which significantly reduces the vasodilation associated with the non-trend, increasing treatment efficiency increased with the fourth week of the incidence of all adverse reactions, no effect on heart rate of expansion of the coronary arteries cases were effective against mild to moderate hypertension better effect on the heart Zhang, improved myocardial oxygen supply but the main site of action is the rate of adverse effects and can not control blood pressure 24 hours a long peripheral vascular system, light to moderate essential hypertension 9O. Of taking no drug resistance, is the ideal 4 effective drug treatment of hypertension, renal blood flow and allows patients the glomerular filtration rate. . . , U no lack of fish, I = £ / oath /,[link widoczny dla zalogowanych], urgent prosperous and I, J expansion,[link widoczny dla zalogowanych], enalapril in patients with congestive heart failure Blood Magnesium 1. z ~ a l / First People's Hospital of Xuzhou (221002) ZHANG Hong-held snow stone roller Diao Southacre enalapril (EN), Department of claim second-generation angiotensin converting j. Enzyme inhibitors, sulfhydryl dismay, the role of angiotensin converting enzyme inhibition than captopril strong and durable. Toxic side effects. In recent years,[link widoczny dla zalogowanych], application of E treatment of congestive heart failure (CHF) has been achieved satisfactory clinical results. Our hospital from 1992 to September 1994 for CHF patients treated with EN. And in the determination of serum magnesium values before and after treatment, and to discuss its preliminary analysis. Materials and methods are presented below one study: CHF patients with a total of 46 patients were all down 29 males and 17 females. Age 23 to 72 years in which patients with coronary heart disease l9, l2 cases of hypertension, rheumatic heart disease in 7 cases, 8 cases of dilated cardiomyopathy. L ~ Iv-level cardiac function (NYHA criteria) Second, treatment: 46 cases were randomly divided into two groups, enalapril group (27 cases): the strong heart, diuretic based on the use EN, dose of 5 ~ 20mg / day. Treatment for 1 month. The control group (19 cases): In addition to not EN, the treatment with the former group. According to the value of serum magnesium before and after medication for statistical analysis. T test with significance. The results of a, EN group and the control group before treatment and serum magnesium values were 0.722mmol / L and 0.724mmol / L. No difference in the two groups (P> 0.05) than normal (O.75mmol / L) is low. EN group after treatment, serum magnesium values (1.087mmol / L) was significantly higher (O.769mmol / L) (P <O.01). Second, EN changes in serum magnesium before and after treatment: 1 month after taking the value of serum magnesium was significantly higher than before (P <O.01). CHF were discussed more than a magnesium deficiency factors exist, and often reduce the blood magnesium. The reason may be t (1) CHF caused by diuretics Hypomagnesemia (2) repeated use of digitalis cardiac stimulant, especially long-term use of digoxin. Increase the excretion of magnesium. (3) CHF when gastrointestinal disorders. Decreased renal blood flow, secondary aldosterone increased and so on. Can affect the absorption and excretion of magnesium, resulting in hypomagnesemia are known to maintain blood magnesium is an important cause of potassium balance. Hypomagnesemia can cause refractory hypokalemia. CHF is not conducive to correct. Experiments show that, as a coenzyme in phosphorylase a decreased concentration of magnesium, so that reduction of energy production, resulting in myocardial metabolic disorder, caused by myocardial necrosis, myocardial contractility and to increase the impact of heart failure. In this paper, EN treatment, CHF patients with serum Mg values significantly increased compared with before treatment, compared with the control group were significantly different EN values of serum magnesium in patients with CHF to improve the mechanism is still not clear at present. CHF in the kidney of one cable to increase the activity of EN-angiotensin system can inhibit the renin-angiotensin system activity index, the index of plasma angiotensin I and aldosterone decreased significantly. Reduced secretion of aldosterone. The urinary magnesium excretion decreased. Increase in magnesium reabsorption. Magnesium levels to rise. Ⅱ decreased vascular tension cable, reduce sympathetic activity, inhibit the biosynthesis of norepinephrine cable and the release of the nerve junction, so that reduction of adrenal medulla catecholamine release, thereby increasing the serum magnesium concentration.