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asbryobvrz · Wysłany: Śro 14:03, 16 Mar 2011

Music Meliet ketones: the trust of non-insulin diabetes treatment drugs

High,[link widoczny dla zalogowanych], and U) L L ratio of tenant is often the same. When a patient with insulin therapy plus when using this product, triglycerides tended to decrease, but when there are increased when the insulin dose was reduced. Thiazolidinedione may lead to cardiac hypertrophy in animals, and FDA 48 weeks of treatment of 154 patients had no change in cardiac mass or function of this product during pregnancy or breast-feeding in women's safety has not yet determined. 6 to enamine test drug interactions can decrease the absorption of the product of about 7O%, · 354 foreign pharmaceutical - manufacturing synthetic drugs Shenghua Yao Jing Dan List 1997,[link widoczny dla zalogowanych],18 (6) Thus, taking the points when serving. 600mg. The product with the same CYP3A4 metabolism by oral contraceptives and terfenadine in combination,[link widoczny dla zalogowanych], can reduce serum latter product is newer oral agents, can reduce the NID of a concentration. DM patients with insulin resistance, glycated hemoglobin concentration of 7 doses of degrees. This product has been FDA approved the combination with insulin, this product This product 2OO,[link widoczny dla zalogowanych], 400mg tablets no scratches, the initial dose can also be used alone, for patients not taking insulin product can increase the amount for a day 2OOnag, the amount used 400n Yao, the highest dose of oral treatment with other drugs. Cheng Han compile terbinafine treatment onychomycosis [Anon. MedLett, 1996; 38 (981): 72] terbinafine (terbinafine) is a synthetic antifungal propylene amine, as a local antifungal agents in the United States had used oral medication is now listed for the treatment of skin fungal infection of nails caused by fungus. 1 nail onychomycosis treatment drug for skin fungal infections often resistant to local treatment. Griseofulvin is the first oral antifungal treatment of onychomycosis, but the treatment must continue for 6 months,[link widoczny dla zalogowanych], the treatment of nail infections are often required 1 year, and the cure rate is very low (<20%), relapse rate higher, although rarely cause serious toxicity, but often headache, nausea and abdominal discomfort. Ketoconazole (ketoconamle) and fluconazole (flueonamle) oral treatment of onychomycosis can be, but the research data of fluconazole only published several articles; and ketoconazole, liver toxicity and drug interactions is that people trouble. Itraconazole (itraeonazole) by the U.S. FDA recently approved for oral treatment of toenail fungal skin infections. However, itraconazole and the other through the cytochrome P450 isoenzyme metabolism of drugs such as erythromycin, triazolam, terfenadine, astemizole (~ stemizole) or cisapride (cisapride) in combination, can produce interactions and cause serious toxicity. 2 antibacterial activity of terbinafine inhibits squalene cyclooxygenase, reducing the synthesis of ergosterol, and ergosterol is an essential component of fungal cell membrane. In vitro tests confirmed that terbinafine for tinea of the skin caused by fungi are highly reactive (stronger than itraconazole), however, in vitro antibacterial activity and the relationship between clinical efficacy has not yet determined. The drug also has activity against Candida albicans, while some of onychomycosis caused by yeast-free activity. 3 pharmacokinetics after oral administration, terbinafine easily absorbed from the gastrointestinal tract, about 2 hours to reach peak blood. In the liver metabolism, with urine and feces. Patients with renal dysfunction and cirrhosis the clearance rate will be reduced. The drug is lipophilic drugs and pro-keratin, the stratum corneum, sebum, hair and nails have a higher concentration. 1 week after starting treatment, the nail clippings can be detected terbinafine, the withdrawal can persist in the nail in the 36 weeks. 4 in 56 cases of clinical trials in patients with toenail fungal infection were found in a double-blind controlled trial of oral terbinafine 250nag, a 131, l2 weeks of treatment, the treatment group 56 patients achieved complete clinical cure 32 cases (57 %), placebo group 55 cases were cured while only 3 (5%); another comparison test showed that oral terbinafine (250nag, day 1 time) and griseofulvin (500nag, day 1 times), l6 weeks after treatment, terbinafine group of 43 patients with clinical cure in l8 cases (42%); griseofulvin group 41 patients, only 1 patient (2%). Toenail fungal infection in patients 52 weeks duration conducted multi-center study found that, day 1 of oral terbinafine or itraconazole 250nag 200nag, l2 weeks of therapy, terbinafine group of 70 patients with 86 cases cured (81%), itraconazole group of 84 patients with clinical cure in 53 patients (63%). In a randomized open-label study found that patients with nail psoriasis oral terbinafine 500nag (I group) or itraconazole 400rTlg (Ⅱ group) El1 times a month l week of treatment, a total of 4 months, or oral terbinafine 250rTlg a 131 (Ⅲ