Oxymatrine combined pHGF critical of the treatment

e707004304 · Wysłany: Wto 1:30, 15 Mar 2011

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Oxymatrine combined pHGF critical of the treatment of acute severe hepatitis B Efficacy

tober, 2005,[link widoczny dla zalogowanych], Vo1.5,[link widoczny dla zalogowanych], No. 2.1 Results 102 2.1.1 Clinical effects of the two groups the incidence of severe hepatitis: the treatment group and 5 patients (16.7%) patients treatment fails, the progress to severe hepatitis. Control group, 11 cases (36.7%) treatment fails, progressed to fulminant hepatitis. Statistical analysis,[link widoczny dla zalogowanych], X10.82,[link widoczny dla zalogowanych], P <0.01. 2.1.2 survivors began to improve after treatment, time and duration of illness: treatment group condition began to improve time to 3.6 ± 1.5d, the control group was 7 .5 ± 3.4d, t = 1.98 (P <0.05), compared the two groups were significantly different. Course of the treatment group survival 41 ± 6.5d, the control group 58.25 ± 8.72d, t: 5.99 (P <0.01), compared the two groups was significant difference. 2.2 before treatment compared blood biochemical indices of the treatment group compared with the control group, liver function after treatment there was a significant difference index (P <0.01). Table 1 The changes in blood biochemical parameters before and after treatment (±) group before and after treatment P <0.01. Compared with the control group before and after the P <001. 3 remains the world to discuss the scope of acute viral hepatitis with acute severe hepatitis in the main J. Meanwhile, more and more severe hepatitis caused by antiviral therapy clinicians attention, especially for those who have a clear hepatitis virus replication and clear virus replication is the main reason for liver injury caused by the sick, to protect the liver cell-free uninfected in viral infection, control disease progression, antiviral therapy is essential. Oxymatrine extracted from Sophora biological alkaline aqueous solution, 98% were oxymatrine, in the human body has a strong anti-HBV effect of the virus, can directly inhibit the hepatitis B virus protein synthesis, improve liver cell function, and regulation of the immune matrine also has other effects, is now widely used in clinical treatment of chronic hepatitis B virus resistant. Our data revealed that 30 patients were treated with matrine patients, HgeAg and resistance to a BU Ding 3c-IgM was positive in 24 patients with high titer patients control their disease within the short term, compared with control group P <0. 05 pHGF suckling pig fresh liver from the peptide extracted active substances, can specifically stimulate cell DNA synthesis, and promote repair and regeneration of liver cells, chronic active hepatitis and severe hepatitis have a good effect, hepatocyte growth factor by reducing the liver cell damage, reduce liver cell necrosis caused by passive fibrosis, regulate immune function, but no direct antiviral activity. In view of the pharmacological effects of two drugs each feature, the combination of matrine's anti-virus, anti-inflammatory, immune regulation, to take pHGF to promote regeneration, the role of blocking apoptosis of liver cells, efficacy complementary can effectively reduce the mortality, safe and non-toxic side effects.