e707004304
ORANGE EKSTRAKLASA
Dołączył: 17 Gru 2010
Posty: 612
Przeczytał: 0 tematów
Ostrzeżeń: 0/5
Skąd: England
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 Wysłany: Pon 12:20, 21 Mar 2011 |
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Pharmacokinetics of theophylline in patients with COPD and its interference factors
· 1.3) h b dckaraJ1ce (cL) waLs (0.07 ± 0.03) The. phyinesenlnlconcentrati. nsdeenTlinedbyHPLCL'h-1. kg a intIlepatientswitI1c0PD. rI1I1erewasn. aJ1duVmeh0dsarehig} llyc. n-elatedaJ1dbotl1caJ1besignificaJ1tdifferenceinVd,[link widoczny dla zalogowanych], tl / 2,[link widoczny dla zalogowanych], andCLbetweenCOPDusedmthecl called caLpham1ac0kmetcsstudy · patientsan (JhealthyV. uneers (P> 0.05) · TheValuesoftl1eophvuine; pham1ac. kinetics; intetion; HLc; uvagedpatientsthanth. sein. ldCOPDpatients (P <uuXiao-ng, c. nsp0ndenceauth . R, rnale0.05). Afteradministrationofnifedipinefor5consecutiveE-mail: L,, myf @ h. TmM.conRelativebioavailabilityofacomplexMetforminplusglibenclamindeformulationinmalevolunteersLIUXiao-ying, CHENTie-feng, YANGMin, YUXi-yong, LINShu-guangResearchCenterofMedicalSciences, GuangdongProvincialPeople'sHospital, Gnangzhou510080, Guangdong, ChinaAM: ToinvestigatetherelativebioavailabilityofthetestcomplexMetforminhydrochlofideformulations (1.25mgglibenclamindeand250mgmetforminhydrochlorideperpellet) andevaluateitsbioequivalenceofthecomplexcomparedwithindividualdrugadminstration.M mouth fc11 】 } 10DS: Arandomized, self-control, two-wayCROSS-overstudieswereconductedin20healthyvolunteersl (24 ± 4) years, (62 ± 7) kg, weightindex (21.0 ± 1.9)] . Onepelletoflestdrugortwopelletsofreference (com-merciallyavailable, 1.25mgglibenclamindeperpelletand250mgMetforminhydrochlorideperpelletrespective-ly) wereorallyadministratedandthealternativeoneswereadministratedafterawashouttimeofoneweek.Serumsampleswerecollectedbeforeandafteradministrationwitl1in24hours.Metforminandglibenclamindeconcen ~ a a
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