Decarbonylation of artemisinin and artemisinin cir

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Decarbonylation of artemisinin and artemisinin circular dichroism

rDichroismofDe0x0qingha0suandQinghaosuYEBin,[link widoczny dla zalogowanych], SHENQi, WUYu-Lin. (ShanghaiInstitute0, OrganicChemistryAcademiaSinica, 200032Shanghai) Abstract: Comparisonoftheopticalcirculardichroismbetweendeoxoqinghaosuandqingh-aosushowsthatthemaximumat258nmintheCDcurveofqinghaosuisanadditiveph-enomenonofthetwochromophores - lactoneandperoxide. Da ~ criptor: Qinghaosu, Peroxide, Circulardichroism peroxide and lactone groups containing artemisinin 1 is a unique structure of sesquiterpene -1]. It is also rather special circular dichroism in the 258nm and 228nm respectively, showed a maximum value and a minimum. Liang Xiaotian made this a great value at 258nm is an illusion caused by turning [2】. Recently, we have to photochemical oxidation reactions were prepared in high yields of artemisinin decarbonylation 2t, we have synthesized previously decarbonylation deoxy artemisinin-3 [', and carbon hybrid 4t ¨ decarbonylation of artemisinin compounds taking into account the three In addition to a carbonyl oxygen atom less and be less of a peroxy oxygen atom or methylene substituted peroxy oxygen atoms, the fully maintain the configuration of artemisinin. Therefore, these three compounds circular dichroism spectrum compared with the artemisinin undoubtedly will receive more specific information. $ Zero circular dichroism testis JASCO-500C-type instrument with the determination of 1,[link widoczny dla zalogowanych],2,[link widoczny dla zalogowanych],3,4 samples were dissolved in methanol, concentration: V. 0027mmol/mL. Circular dichroism is shown below, the curve for the compound 1,2,3,[link widoczny dla zalogowanych],4 1,2,3,4 spectral lines, respectively, compared with curve 5 minus the spectrum of compound 1 compound 2 lines. Stone to the map by the decarbonylation of artemisinin can be 2 shows the spectrum of a positive, non-polar values. The line,[link widoczny dla zalogowanych], such as artemisinin, after subtracting the spectrum only shows a single minimum, the Extreme Blue moved to 224nm, Ae is also increased to a 1.58. That artemisinin curve Jan. 15, 1990 Received, 1990:8, 31 BU _ repair IV. Natural Science Foundation of quiet family support classes. 640 Organic Chemistry 1991, Coke _l1. The emergence of a maximum value in the peroxide is really the positive negative base curves and lactone formed by superposition of curves, compound 3 and 4 from the flat line is not only consistent with the theoretical speculation, but also further explanation 2 indeed positive line formed by the peroxide. Thesaurus. Qing Han Su, peroxy compounds, circular dichroism