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asbryobvrz · Wysłany: Czw 8:02, 24 Mar 2011

Rational use of the elderly

Small dose of medication should be started one by adding to the individual the most appropriate therapeutic dose satisfactory. Pharmacopoeia of people over the age of 60 applications of adult doses of 3 / 4, but in general, should be based on age, weight, physical condition, the adult dose of I / 5, I / 4, I / 2,2 / 3,3 / 4 order of drug use, even with this method is also due to the elderly individual and vary widely. The best way is to test blood drug concentration and decreased renal function adjust the dose of the implementation of individual administration. Chinese medical research and clinical. January 2006 l1. Volume 4. S! L shed the milk teeth 3.4 Although informed by the best time of medication administration by the intestine, especially in stimulating digestion and props drugs such as antibiotics cable, iron and other general administration of the meal, but stomachic, choleretic drugs , antacids, gastrointestinal spasm drugs, laxatives and other salts should be served before a meal. Oral drug absorption,[link widoczny dla zalogowanych], blood concentration, metabolism, and excretion of 73 exchange of experience by changing their circadian rhythm caused by changes in drug effects. Therefore, the best understanding of the drug control administration time rhythm changes is to increase the efficacy of the important measures to reduce adverse reactions. Received 2006-09-19】【caution aspirin Lv Jungang Sun Jingjing Yao Jiachun Yang Haide Key words Key words in the ring with caution aspirin l17, 969.3 Document code lB Article ID: 1726 - 4855 (2006) 11-0073-01 aspirin analgesic detoxification, anti-inflammatory, anti-rheumatic, inhibiting platelet aggregation and other effects. More extensive clinical use, short-term adverse effects of small doses less long-term side effects when more extensive use. If the abuse can cause serious adverse reactions, the following should be used with caution or disabled aspirin. l aspirin in the acidic stomach environment, the patient can not be ionized, and the original dissolved in acid,[link widoczny dla zalogowanych], can directly stimulate the corrosion of the gastric mucosa, the original lipophilic can penetrate the epithelial cell membrane, and inhibition of cyclooxygenase (COX) activity interfere with stomach and duodenal mucosal cells, decreased prostaglandin (PO) and synthetic gastric juice, damage mucosal barrier, the protective effect of gastric mucosal cell loss caused by gastritis, gastric ulcer, or bleeding or gastric perforation. 2 kidney disease patients, diabetic patients, liver disease patients aspirin affect renal blood flow, reduced glomerular filtration rate,[link widoczny dla zalogowanych], reduced sodium and water excretion, increased PG metabolism, causing kidney damage. High doses can cause blood sugar, urine sugar increased. Long-term dose (> Ig) when the liver drug metabolizing enzyme salicylate combined with the ability to reduce the accumulation of metabolites, can cause liver cell necrosis, elevated ALT, can cause serious liver damage, elevated blood ammonia, are reversible after discontinuation restore 3 of people with asthma, aspirin allergy acetylation in vivo formation of protein antigens can induce allergic reactions such as urticaria, etc.; while aspirin inhibition of COX and PG synthesis blocked by arachidonic acid (AA) generated by LT and other ester oxidase metabolites cause bronchial spasm, causing asthma,[link widoczny dla zalogowanych], serious cause death. L units of hospitals in Beijing Armed Police Corps three subjects' Beijing 100027) 4 cerebral hemorrhage, cerebral embolism in patients with low-dose aspirin (40 .--, 80mg average 50rag) inhibition of COX, prolonged clotting time, increased bleeding; high dose ( 0.3g or more) can inhibit the vascular wall, including the PG synthase, reduce the synthesis of PGI2. PGI2 is a physiological antagonist of TXA2, GPI2 reduced synthesis, can promote blood coagulation and thrombosis. 5 Aspirin can cause the elderly to reduce renal blood flow, renal papillary necrosis, absorption, hydrolysis and acid to salt form, most of the excretion by the kidneys. Insufficient blood supply due to various organs of the elderly cases, prone to toxic reactions called salicylic acid reaction. 6 children suffering from HIV infected children and young people, aspirin may be complicated by Beye's syndrome, neurological symptoms appear, can be deadly. Survivors without prompt treatment, brain tissue will be damaged, leaving sequelae (such as mental retardation, slow growth, movement disorders,[link widoczny dla zalogowanych], etc.), so caution children, especially infants and children under the age of 3 should not be used. 7 pregnant women, aspirin into the body, in order to free type salicylate through the placenta into the fetus, causing birth defects, inhibit platelet aggregation, can cause vaginal bleeding during pregnancy or after childbirth, pregnancy, prolonged fetal death rate increased. Therefore pregnant women should avoid the use of drugs containing aspirin, especially in pregnancy 20d ~ 3 months. In short, when our long-term use of aspirin to monitor blood concentration; adults in the 200 ~ tg / ml below, children 20 ~ tg / ml or less. Avoid adverse reactions. 【2006-08-29】 Received Date