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This study involved normal mice, and transgenic, Alzheimer's mice. Mice were given either caffeine-supplemented water or plain water. Mice were tested for performance in a watered maze system that the mice navigated to reach a reward goal. Further, after maze tests were completed, both blood and brain tissues of all mice were examined.
These findings prompted Drs. Arendash et al. to study the effects of caffeine consumption on special, transgenic, aged mice with Alzheimer's amyloid bodies.
Alzheimer's Disease and related dementias affect some 30 million people in the world (Alzheimer's Disease International). Alzheimer’s disease (AD) currently afflicts 5.3 million Americans, and treatment of this disease, together with other dementias, triple healthcare costs for those age 65 and older (2009 Facts and Figures of Alzheimer's Disease, Alzheimer's Association).
Alzheimer's patients and people without dementia were compared for dietary differences. Drs. Arendash, Cao, Potter and coinvestigators of the University of South Florida noted that Portuguese research found less caffeine consumption by Alzheimer’s patients compared to patients without dementia (based on the most recent, last 20 years of their lives). Other uncontrolled clinical studies have reported moderate caffeine consumption may protect against memory decline with age.
Alzheimer's Disease and Caffeine Relationships
Here are points to remember. Caffeine
Memory loss and failure to perform simple memory tasks are characteristic of Alzheimer's disease. Sticky, amyloid protein is present in the blood and the brain of AD patients. This protein blocks brain neuronal signals and causes dysfunctional thinking. The disease is devastating and eventually causes death.
Alzheimer's Disease and Caffeine [link widoczny dla zalogowanych], Concluding and Summary Ideas
Although mice and people are different, and animal experiments do not always mimic human experimental results, this study with mice indicates that ingestion of appropriate amounts of caffeine in water, coffee, tea may help reverse or slow Alzheimer's disease. (Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer’s Disease Mice. Gary W Arendash, et al. (July 2009) Journal of Alzheimer’s Disease, Volume 17:3.)
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55 mice were altered genetically to develop an Alzheimer’s disease (AD) over time. When these mice showed signs of memory impairment at 18 to 19 months (equal to 70 human years) [link widoczny dla zalogowanych], half the mice were given caffeinated drinking water. Control mice got plain water.Two months later [link widoczny dla zalogowanych], maze experiments showed that caffeinated AD mice performed almost equivalent to normal mice without brain disease. Control, uncaffeinated, AD mice performed poorly.Caffeinated Alzheimer's mice also had significant reductions of harmful blood and brain amyloid protein. This result showed suppression and reduction of up to 50% of the amyloid protein.Caffeine affected two enzymes needed to produce beta amyloid protein. Each enzyme activity decreased.Control normal mice, whether caffeine-treated or not, performed equally well to each other, and showed no evidence of AD or amyloid protein.
The experiment was as follows:
Alzheimer's Patient Mice and Caffeine Experimental Results
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(Caffeine Suppresses Amyloid-β Levels in Plasma and Brain of Alzheimer’s Disease Transgenic Mice. Chuanhai Cao, et al. (July 2009). Journal of Alzheimer’s Disease, Volume 17:3)