Cyclophosphamide combined with local and 5 - fluor

e707004304 · Wysłany: Sob 12:25, 19 Mar 2011

Cyclophosphamide combined with local and 5 - fluorouracil in the treatment of 23 cases papilloma external auditory canal

ZHANG Zhen-ming Yuan Yiming (Gansu Provincial People's Hospital Pharmacy. Lanzhou 730000, China; - Second Affiliated Hospital of Lanzhou Medical College,[link widoczny dla zalogowanych], Lanzhou, 73003 .. ()) CLC R987 papilloma canal is more common benign tumor, but there is a tendency to malignant , commonly used in clinical surgery, but its high recurrence rate, especially for those more likely to relapse broader base. We tried local injection of cyclophosphamide (CPA) and a bit 5-fluorouracil (5 to FU) method of treatment of papilloma of the external auditory canal 26 ears in 23 cases, satisfactory effect, reported as follows. 1 General information 17 male and 21 ears and 6 females, 5 ears, aged 35 to 60 years of age, duration of 2 months to 1 year. Most patients have a habit of digging ears. Cartilaginous external auditory canal tumors in 17 ears in 15 cases,[link widoczny dla zalogowanych], including broad-based multiple, 8 cases of 10 ears. Bony external auditory canal tumors in 8 cases of 9 ears, those who are multiple sessile. Complete obstruction of the ear canal tumors in 13 ears. 2 routine disinfection of the external auditory canal after treatment with 5 slender needles to inject CPA10 ~ 20mg in tumor at the base, sessile by appropriate multiple incremental 5 ~ 10mg,[link widoczny dla zalogowanych], 1 injection per week, while a joint with 5 FU injection (10ml the increase with 0.5ml dimethyl sulfoxide) bit 2 to 4 drops / time, 3 times / d, l 1 weeks of treatment. Repeated after 1 course of treatment, such as the tumor has not disappeared in the same method repeated treatment. Clinical Efficacy of 3.1 3 26 ears in 23 patients, two courses, the tumor elimination 1998-11-24 Received ,1998-12-21 Revised lost 15 ears in 13 cases, 3 sharp stick in mobility after treatment in 7 cases 7 ≮, 4 and 3 cases disappear after treatment 4 ears. 3 lots of hair lines disappear after treatment sessile tumor. Tumor disappeared after treatment during the day Shu mild swelling, followed by the gradual erosion of mass, Hui contraction followed up for 2 years without recurrence disappeared in 19 ears, rarely 1 year 6 months 5 ears without recurrence 6 months in 2 ears . 3.2 The risk of side effects during treatment of micro-line round the ear pain j south, mild localized swelling of the tumor base, but a gradual deletion of a Shu}, no tinnitus and deafness and intestinal reactions. End of treatment, patients clamor after dark laboratory tests,[link widoczny dla zalogowanych], WBC and platelet count were normal 4 to discuss local CPA combined with 5FU treatment of external auditory canal with access to such effect papilloma, the former may inhibit the DNA synthesis in ① CPA, 5, inhibition of DNA synthesis of a FU enzyme, while two-way non-shabu small roar of anti-tumor handsome, so anti-tumor: use to enhance; ② direct local high concentrations of anticancer drugs for}} {J: cancer, clinical Xin can play The J,[link widoczny dla zalogowanych], blocks tumor cell growth and reproduction of the system by quickly mantis, direct EL '. . ③ local high concentration of 5 m for a FU can induce tumor control inflammation sneeze 【plug, resulting in tumor nutrition by the I {H, to speed the tumor necrosis jJII 『I} 2 down. Local use of anti-tumor drugs Hr Bu, can be reduced baskets cut the body of the odd effect and adverse reactions. Local MS C'Pz 5 FU treatment of the ear canal of a papilloma is effective and the method is simple