Genetic epidemiology of neural tube defects and ge

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Genetic epidemiology of neural tube defects and genetic counseling of

Magnesium related. We will be in areas of high and low in areas of climate (climate, precipitation), diet and other factors and the relationship between the prevalence of organized into Table 11, Table 12. From this. Higher temperatures, more rainfall, dietary diversification, leafy green vegetables, meat, fish, shrimp more areas, the areas where the prevalence of characteristics of low moisture, compared with Han Ling, dry, monotonous diet varieties, cereals and potato class more green vegetables thatch = n i flutter flutter dang} Regardless of the ship he ∞ ¨ ∞! ii twist twist boat shouted to ∞ Volume 1 2 37 * Lecture, multi-gene disease research progress and strategy of the Chinese Academy of Medical Sciences and Peking Union Medical University, Institute of Medical Genetics, Beijing National Center for Genetic Medicine (~ 100005) in Three Lan Guan Si Lan Dan limonene 1 Ba with the human genome,[link widoczny dla zalogowanych], progress in terms of human genetic disease research, especially cloning of disease genes, has made impressive breakthroughs. However, most diseases and Seoul does not match the dominant chromium Taiwan Meng or recessive inheritance pattern, which may involve more than one gene, the multi-gene disease. for these multi-gene diseases, medical and biological research has become the first tangerines. more than one gene in the prevalence and severity of disease, the most damaging to human that multiple genes Tanbing,[link widoczny dla zalogowanych], such as cerebrovascular disease, diabetes, heart gene obese gene I-sI. disease, cancer, cause of death for the population of the country to find the top three causes of death accounted for 2 / 3. Beijing each year from cardiovascular disease mortality of about j million new cancer patients each year Shanghai has 30,000 down, the national prevalence of hypertension up to l】 Koo, patients hundred million people. Here the disease in clinical or epidemiological Luk has a certain degree of family orientation,[link widoczny dla zalogowanych], but not the performance of genetic pattern typical glenoid Del. in medical genetics as , the fish, shrimp more, suggesting that these factors may be environmental factors for the disease. 11 wrapped around the climate and lack of whipped prevalence of neural tube 12 wrapped around the ingredients Koo (g) and the prevalence of neural tube defects (‰) of wheat grains to give patients the prevalence of potato cabbage 131722t63263913610 Hebei, Shandong, Shanxi 111793573312087412 1511392442383687430 Shanghai, Shenyang 11346265lO017810631 45944043651174910.18.22 ~ 1.601B45239137135333.5441330.613.3 disease Koo 2.90 ‰), (Carter, London)} 5.64 ‰ (prevalence rate 5.60 ‰) (R [chards, Glasgow) l8 .87 ‰ (prevalence rate 8.70 ‰) (Nev ~ n,[link widoczny dla zalogowanych], Belfast); 3.1O ‰ (prevalence rate 3.O0 ‰) (Czeizel, Hungary). These are prone areas, with the group in areas of high prevalence of Gu close compatriots. Compatriots in areas of low prevalence in France is 2 ‰ (illness Koo as 1 ‰). And low-prone areas close to the group, marriage and fertility rate is low because of the disease. Therefore, Ku is very low prevalence of parental progenitor; offspring prevalence of little information. Carter fell 202 spina bifida survey, only 5o looking down fertility, its progeny, only 2 101 pour down the incidence (2). According to the report of the disease Peter Nevin Tan aunt and uncle and cousins have a lower prevalence and may be lower than or close to the population prevalence of this phenomenon was similar to this. Nev [n that may be included as often stillborn child without the brain, therefore adverse effects of factors involved. The inheritance of the disease,[link widoczny dla zalogowanych], it has been that single-gene genetic screen, even for the line mitochondrial genetic (Namce). But the base is generally believed that genetic explanations with more reasonable (Carter, Nev ~ n, Cze ~ zel, etc.). The heritability of the disease abroad, calculated according to the findings of family as 6O, with the group to those of low-incidence areas, slightly lower than the high incidence in this group. 3.4 Experience value of foreign genetic counseling is proposed in high-prone areas, after children have birth to a regeneration rate of 5.9 children reassert risk; have to have two children, the risk was 12 ‰ ~ reassert 2O%. In low-prone areas, have birth to a children, its siblings reassert the risk rate of about 2.5 ‰ ~ 3.0 ‰. Is not yet seen the report the calculation of genetic counseling. According to the group in areas of high incidence and low-prone areas and the inheritance of computer use with the above calculated the corresponding rates of recurrence risk was cut as I. 77 ‰, l】. 37 ‰ and 1.58 ‰, with foreign values closer. 7