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yxfbbiedtj · Wysłany: Pon 16:02, 21 Mar 2011

Clopidogrel non- ST segment elevation acute coronary syndrome

Low molecular weight heparin and aspirin and other applications ,[link widoczny dla zalogowanych], 14d cardiovascular death, myocardial infarction,[link widoczny dla zalogowanych], the incidence of recurrence of angina was still as high as 17.8%, 20%, 15.1% t21,[link widoczny dla zalogowanych], anti-platelet research collaboration ~ (AVTC) meta-analysis suggest that aspirin can reduce cardiovascular death , new myocardial infarction and the risk of recurrent ischemia , but still can not meet the clinical needs [31 , requiring a new treatment to reduce cardiovascular events Dangerous. Aspirin by inhibiting cyclooxygenase , preventing arachidonic acid into prostaglandins and thromboxane A: The way to inhibit platelet aggregation. Ticlopidine play a full role in the anti- platelet drugs to be delayed to after 7 ~ 8d,[link widoczny dla zalogowanych], thereby limiting the drug 's use in acute effects. New thienopyridine derivative clopidogrel is a potent inhibitor of platelet aggregation , 300mg loading dose to achieve steady state after the 2h that anti-platelet effect. The mechanism for the inhibition of ADP -induced platelet membrane glycoprotein Ⅱ b / IIIa fibrinogen receptor binding site exposure. Inducer also caused inhibition of platelet fibrinogen and platelet GPIIb / IIIa receptor binding [ 41, with rapid and sustained antithrombotic effect. This inhibition is specific, does not affect cyclooxygenase or arachidonic acid metabolism. CURE trial showed no ST -segment elevation acute coronary syndrome in patients with clopidogrel and aspirin combination , so that the major cardiovascular events were significantly reduced 20% t51. Our clinical studies have shown that in non- ST segment elevation ACS continued treatment . Composite end point clopidogrel group than in the conventional therapy group , P <0.05, significant difference , and no bleeding tendency , no side effects such as neutropenia . In summary, clopidogrel in reducing non- ST segment elevation acute coronary syndrome in patients with recent (14d1 cardiac event is safe and effective ,[link widoczny dla zalogowanych], and worthy to be popularized . 【
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