Anti-inflammatory effects of total saponins of Pan

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Anti-inflammatory effects of total saponins of Panax japonicus Experimental Study

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05.1156-02ExperimentofAcuteToxicityofAndrographolideDerivativesZHAINa, XUQi-tai, SONGPei-ran, CHENBai-quan (HenanUniversityofPharmacologicalCollege, Henanng475004, China) Abstract: 0bjectiveTostudytheacutetoxicityofandrographolidederivatives. MethodsActivityconditionanddeathconditionofmusculusalbuswereobservedwithinfourteendayswithintragastricallyandpefitoneMinjection. andthemethodofkrherwasusedtodetermineLDnofandrographolidederivativestomusedUSalbusandcorgidenceleve1. ResultsandConclusionThetox-icitymanifestationhadtremendousdifferenceduetodifferentadministrationroutes, forinstance, LDnoftheoraladministrationwaiggerthanthatofperitonealinjection. Thetoxicityofandrographolidederivativesisverylow, belongstOlowtoxicity, butthosecanstimulateeyesandinfluencestomachtosomeextent. Keywords: AndrographolideDerivates; LD50; Experimentofacutetoxicity andrographolide ... (andrographolide) plants for the Acanthaceae Andrographis An-drographispaniculata (Bum.f) Nees extract derived diterpene lactones,[link widoczny dla zalogowanych], is the main active ingredients of Chinese medicine Andrographis paniculata, one of clearing and detoxifying, cooling swelling and other functions. Modern pharmacological studies have shown that andrographolide and its derivatives have anti-inflammatory anti-bacterial, anti-virus, anti-tumor, immune regulation, treatment of cardiovascular and cerebrovascular diseases, liver gallbladder and anti-fertility and other functions. In view of the many effects of andrographolide, andrographolide derivatives of dedicated staff, more and more new derivatives continue to emerge. In order to ensure Received Date :2007-07-25; revision date :2007-09-26 by Profile: Di Na (1980), female (Han), Hebei Bazhou people, now College of Pharmacy, Henan University postgraduate students, degree. Mainly engaged in research communications Pharmacology Author: Xu Qitai (1955 a), M (Han), Zhoukou who is currently Professor of Pharmacy College of Henan University, degree, major in Pharmacology research. * 1156 * Synthesis of andrographolide derivative security, the author made some new derivatives acute toxicity. 1 Equipment 1.1 animals mice,[link widoczny dla zalogowanych], weighing 18-22g, male and female, fasting before the experiment 12h, can not help but water. Purchased from the Experimental Animal Center of Henan Province. 1.2 The equipment balance, graduated cylinder (25m1), gavage needles, syringes (1m1), beaker (50m1),[link widoczny dla zalogowanych], glass rod, a small cage. 1.3 Reagents and drugs 0.5% CMC-Na solution, sesame oil, DMSO,[link widoczny dla zalogowanych], andrographolide derivative samples l,[link widoczny dla zalogowanych], 2,3,4 (from the School of Pharmacy, Henan University Institute.) 2 Experimental methods and results fed 2.1 2-l · 1 method because the toxicity of andrographolide has not been reported, so all the samples with the greatest concentration of 4 dissolved in 0.5% CMC-Na solution, respectively 0 .2 ~ ti.