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Bifidobacterium lipoteichoic acid on D-galactose induced aging phenotype of mice

Quality of physiological functions, such as cell adhesion to the lower matrix protein, bone cells from the adhesion of bone collagen is into. Start a prerequisite for bone formation J, addition of bone mineral deposits of collagen molecules have the characteristics of J, thus inhibited the formation of collagen, the same will result in reduced bone mineral deposition, resulting in calcium, phosphorus,[link widoczny dla zalogowanych], magnesium and other elements of the reduced inhibit bone formation, resulting in senile osteoporosis. The results suggest that weight reduction of the backbone of aging mice, bone calcium, bone phosphorus content was significantly reduced; serum calcium increased significantly. The mice treated with bifidobacteria LTA decreased serum calcium,[link widoczny dla zalogowanych], bone dry mass increased, calcium, bone phosphorus content was increased,[link widoczny dla zalogowanych], indicating that LTA Bifidobacterium bone loss can improve the situation of aging mice and calcium metabolism. NO is an important messenger molecule in vivo and neurotransmitters, with a wide range of physiological functions in the regulation of blood pressure, maintaining vascular tone, inhibiting platelet aggregation and white blood cells on the role of the vascular wall mural and the prevention of atherosclerosis in the formation and development work, NO vasodilatory activity was reduced in the elderly may be prone to high blood pressure and body atherosclerosis one of the reasons. The results suggest that NO decreased aging mice, LTA content of the treated mice than the old model of NO were significantly increased. Description of Bifidobacterium LTA can prevent aging mice reduced NO levels. In summary, Bifidobacterium lipoteichoic acid to an overall improvement in D galactose induced aging mice senescent phenotype, from the tissues, organs and the overall level of the initial proof of anti-aging effect of the LTA,[link widoczny dla zalogowanych], for further study from the molecular level LTA role of anti-aging provide a basis for the development of Bifidobacterium components to provide a theoretical basis for preparation. 【
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