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yxfbbiedtj · Wysłany: Pią 4:07, 11 Mar 2011

Hepatitis C virus core protein increases inducible nitric oxide synthase gene promoter transcription activity

957bp of DNA fragment of the reporter gene construct pCAT3 a iNOSp carrier. Application of the reporter gene CAT transient expression system cotransfected with pcDNA3.1 ( a) a core co-transfected LO2 cells,[link widoczny dla zalogowanych], measured cotransfected pcDNA3.1 ( a) a core/pCAT3-iN () Sp of the expression of CAT Significantly enhanced , is CAT3-Basic empty vector l1 times are pCAT3-iN () Sp 6 times , indicating that HCV core protein on iN () S gene promoter with trans- activation , transcriptional activation of iNOS gene promoter activity Show that HCV core protein can increase iNoS promoter activity , and thus increase iN () S gene expression, and with the increase in the amount of HCV invasion ,[link widoczny dla zalogowanych], iN () S will increase the expression ,[link widoczny dla zalogowanych], HCV core protein increased iN () S Gene promoter activity in a dose dependent manner. This study further verified in the normal liver cells, the HCV core protein increased iN () S gene transcription activity. No , as a multifunctional signaling molecule , involved in the liver cells very wide range of signal transduction processes , when the HCV invasion of liver cells after a series of physiological effects caused by increased iN () S gene promoter activity of N ( ) production ,[link widoczny dla zalogowanych], disrupting N () of the signal transduction process,[link widoczny dla zalogowanych], which involved in the pathogenesis of HCV ( cancer) process, in which specific mechanism needs further study.