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A composition or sequential regimen in which calcipotriene ointment was applied in the a.m. and halobetasol ointment applied in the nightfall as 2 weeks. That regimen testified apt be superior to monotherapy with halobetasol ointment twice daily or calcipotriene ointment twice journal as 2 weeks. A weekdays calcipotriene and weekends steroid sequential therapy is also very fashionable deserving to its high efficacy and low side achieve silhouette.
How Does Calcipotriene Work in Psoriasis?
Calcipotriene [link widoczny dla zalogowanych], in the concentration of 50microgram/gm ointment, has been shown to be efficient and secure for use in children while managed up to 45 g per week per square measure of body area.
Further ReadingPsoriasis Treatment GuidelinesDisclaimer
Plaque psoriasis responds well to calcipotriene. Calcipotriene solution is profitable in scalp psoriasis and hook psoriasis.
Next: Does Stress Cause Psoriasis?
In clinical trials the effectiveness of calcipotriene in psoriasis was shown to be comparable to or slightly better than level II corticosteroid ointments such as fluocinonide 0.05% used as 1 of the topical therapies for psoriasis . In trials in which calcipotriene was likened with anthralin [link widoczny dla zalogowanych], it feed well in terms of clinical efficacy and was accepted by patients for it does not taint as much as anthralin and is fewer irritating. Hence it is preferred over anthralin in topical dispose of psoriasis .
The mechanism of operation of calcipotriene is via vitamin D receptor intervened effects on the proliferation and differentiation of the keratinocytes [link widoczny dla zalogowanych], the epidermal compartments of the rind. Studies have also shown behavior aboard the immunological features of psoriasis.
Side Effects of CalcipotrieneLocal irritation is the maximum frequent side effect of calcipotriene, affecting 20% of remedied patients.Vitamin D and its analogues have the potential to bother the calcium metabolism and cause elevation of calcium in the blood and urine. Hence it is exhorted that the dosage of 50 gm per m2 of body place of calcipotriene should no be exceeded in adults.
Calcipotriene is not as effective as super potent topical corticosteroids, but regimens in which patients apply both calcipotriene and super potent corticosteroids have demonstrated superiority over either agent alone.
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What is Sequential Therapy in Psoriasis?
How Effective is Calcipotriene in Psoriasis?
Calcipotriene is not as effective as super potent topical corticosteroids, merely regimens in which patients apply both calcipotriene and super potent corticosteroids have demonstrated superiority over either agent single.
Which Types of Psoriasis are Treated With Calcipotriene?
Calcipotriene ointment has been shown to enhance the efficacy of PUVA and UVB phototherapy in psoriasis. Calcipotriene used in combination or as a sequential therapy with potent steroids boosts the effectiveness of either agents.
Is Calcipotriene Safe For Use in Children?
The information given in this treatise is for educational intention merely so that patients are conscious of the alternatives obtainable. No diagnosis should be made or treatment undertaken without 1st consulting your medic. If you do so, the author or suite101 ambition not be responsible for anyone consequences. The images invested are for illustration purpose merely.