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yxfbbiedtj · Wysłany: Sob 17:08, 05 Mar 2011

Cytokines in ischemic cerebrovascular disease role

TNF ... II1 and 7 an interferon (IFN-Y) the interaction is complex, PAF stimulated monocytes and macrophages synthesis of IL-1 and TNF. In turn,[link widoczny dla zalogowanych], TNF, IL-I and IFN stimulation of a 7 and monocytes, macrophages and other cells to synthesize PAF, which became a feedback loop. PAF in the regulation of mouse cells to produce a single eucalyptus IL-l plays an important role. When the role of PAF in rats with lipopolysaccharide stimulated macrophages, the biphasic response occurs in the micro-ml concentration, PAF stimulation of IL-1 synthesis and release and 0.1nM dimension, IL-j decreased significantly, results show that,[link widoczny dla zalogowanych], PAF may act on two different types of mononuclear cells or the same cells or different cells of two different receptors. However, in the absence of lipopolysaccharide when stimulated with PAF on IL-1 synthesis and release is not obvious. PAF's mechanism of regulating IL-1 is not yet clear, may be increased by a single lipoxygenase Eucalyptus cell metabolism, such as leukotriene B4 (LTB4) increased IL-I synthesis addition, PAF also regulates interleukin 2 production. 4PAF antagonist D 'of the PAF receptor antagonist, is the fat from the Chinese almond extract, and has been considered antagonistic role of PAF on the most effective antagonist of the brain. It can reduce the reperfusion period after ischemia secondary nerve damage,[link widoczny dla zalogowanych], reduce the 289 * cerebral edema. increase the cortical concentrations of ATP and phosphorylation of choline. improve cerebral vascular resistance, improve brain function recovery. Hofer found: BN5202I improve the forebrain and brainstem cerebral blood flow. At the same time reduce the free fatty acids significantly improved the aggregation, BN52021 improve nerve function may be related to improved mitochondrial respiratory function on. PAF single eucalyptus cells regulate the synthesis and function of the release of IL-i was antagonized by BN52021, BN52021 prevents PAF induced hypotension in mice similar structure and structure of the PAF antagonist CV6209 and the different Y gene expression of a 24,180 capacity inhibition in PAF-induced responses. on the synaptic membrane and mitochondria Results station locations, PAF antagonistic agent on the affinity of inconsistency,[link widoczny dla zalogowanych], BN52021 on the synaptic membrane is stronger than microsomal membrane, while the CV of a 6209 has proved the contrary, PAF analogues CV3988, CV6209, BN52I15 and semi-ring compounds L-658731, BN50727,[link widoczny dla zalogowanych], BN50726 and WEB 2086BS is a competitive inhibitor, BN52021 is a non-competitive inhibitor of PAF and epinephrine increase the cloning and cholinergic Cloning of the level of intracellular calcium and neurotoxicity can be antagonized by CV 3988 in a rat after middle cerebral artery occlusion given PAF antagonists can reduce infarct size Apafant.