lin06900
ORANGE EKSTRAKLASA
Dołączył: 22 Lip 2010
Posty: 449
Przeczytał: 0 tematów
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Wysłany: Nie 10:56, 24 Kwi 2011 |
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one study
Materials and Methods
【papers Key words transient high prolactin; in vitro fertilization and embryo transfer; human chorionic gonadotropin; clinical pregnancy
IVF - in the transient hyperprolactinemia on pregnancy
】 【Abstract: Objective: To evaluate the Impact of serum prolactin conncentration on the day of human chorionic gonadotropin (hCG) administration on clinical outcome of in vitro fertilization and embryo transfer (IVF-ET). Methods: 202cycles of IVF- ET / ICSI-ET performed in Reproductive Medical Center of the First Affiliated Hospital,[link widoczny dla zalogowanych], Sun Yat-Sen University of Medical Sciences from October 2005 to March 2008 were analyzed retrospectively. Results: Patients were divided into four groups according to serum prolactin concentration (≤ 30ng / ml (A group),[link widoczny dla zalogowanych],> 30 ~ ≤ 60ng/ml (B group),> 60 ~ ≤ 90ng/ml (C group),> 90ng/ml (D group)) on the day of hCG administration. Implantation rate was 22.20%, 19.75% and 11.83% respectively and pregnancy rate (PR) was 25.00%, 42.70%, 27.30% and 5.88% respectively in this 4 groups. In prolactin> 90ng/ml group, implantation rate and PR were low, comparing with other groups. The difference was statiscally significant. Conclusion: During controlled ovarian stimulation, serum prolactin conncentration was much higner than basal level. Implantation rate and clinical pregnancy rate significantly decreased when serum prolactin concentration dramatically increased (> 90ng/ml). To improve the clinical pregnancy rate of IVF-ET, tight monitoring and appropriate intervention are needed for patients with abnormal prolactin level during controlled ovarian stimulation.
in vitro fertilization - embryo transfer of controlled ovarian stimulation (controlled ovary stimulation, COS) process, the change of serum prolactin in the outcome of IVF-ET, few reports of domestic and foreign, and mixed results, this study retrospectively analyzed our center in October 2005 ~ March 2008 202 IVF-ET cycle, information, reports as follows.
study for the October 2005 to 2008 In March the First Affiliated Hospital of Sun Yat-sen Center for Reproductive Medicine, received in vitro fertilization - embryo transfer (IVF-ET) / intracytoplasmic sperm injection - embryo transfer (ICSI-ET) in infertile patients,[link widoczny dla zalogowanych], a total of 197 202 patients treatment cycles included in the scope of the study. Exclusion criteria: a prolactin secreting pituitary adenoma,[link widoczny dla zalogowanych], or a history of abnormal patients. The reasons for infertility include male factors in 56 cases, 103 cases of female tubal factor, pelvic adhesions in 15 cases, 17 cases of endometriosis and the other 11 patients (ovulatory disorder, and many unexplained failures of artificial insemination, etc.).
[Abstract] Objective To investigate the in vitro fertilization and embryo transfer (IVF-ET),[link widoczny dla zalogowanych], the injection of human chorionic gonadotropin (HCG) at Serum prolactin (PRL) concentration on the pregnancy. Methods A retrospective analysis in October 2005 ~ March 2008 202 in vitro fertilization and embryo transfer cycles in the data. Results in controlled ovarian stimulation (COS), press the injection of HCG in serum prolactin concentration at 4 different points, followed by ≤ 30ng/ml (A group),> 30 ~ ≤ 60ng/ml (B group),> 60 ≤ 90ng/ml (C group),> 90ng/ml (D group). Grown in vitro fertilization and embryo transfer rates were 11.76%, 19.71%, 12.72%, 2.22%; clinical pregnancy rate was 25.00%, 42.70%, 27.30%, 5.88%. PRL>> 90ng/ml group implantation rate and clinical pregnancy rate was lower than the other, the χ2 test, P values were 0.011 and 0.009, were statistically significant. Conclusion controlled ovarian stimulation based on serum prolactin levels were significantly higher than that, HCG injection was significantly higher in serum prolactin (> 90ng/ml), the in vitro fertilization and embryo implantation rate and clinical pregnancy rate decreased significantly. Process proposed COS patients with abnormal prolactin levels closely monitored and given appropriate intervention to help improve the clinical pregnancy rate.
【Key Words】 transitory hyperprolactinemia; in vitro ertilization and embryo transfer; human chorionic gonadotropin (hCG); clinical pregnancy More articles related to topics:
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