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ORANGE EKSTRAKLASA
Dołączył: 26 Paź 2010
Posty: 812
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Wysłany: Sob 23:25, 06 Lis 2010 |
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Problems in traditional Chinese medicine tablet
Lobes lobes is empty plain film after the release from the mold cracking phenomenon. Our experience that, first, pressure regulator properly. Second, the grain is too dry or too wet. The site of pressure films pressure recovery rate flexibility, combined with uneven particle size (not all of its water content), when the tablets out of mold, by scraping a small pink sheet impact, easy to crack. Particles too dry, not easy to form a solid bridge, low stress, high elastic recovery and easy lobes; particles humidity, that affect the mobility of particles, but also easy to stick red, heavy flash chip and tablets to increase, if the reduction of pressure can be decrease in hardness result tablets, but can also lead to increased pressure within the flexibility of tablets of increased stress, increased elastic recovery rate, easy lobes. Solution: First, slow down the speed appropriate to extend the compression of time; adjust the appropriate pressure to reduce the elastic stress, control the amount of magnesium stearate, lowering the elastic recovery rate. Second, control of particle moisture content (3% is most appropriate) and particle size uniformity. Chinese herbal extracts granulation wetting agent if water is made of soft material so sticky that granulation difficult. Responses: 75% ethanol as wetting agent, addition of 1300 ~ 1500 ml / 10 kg, stirring time generally 8 to 10 minutes is appropriate, and immediately pelleting. Easy to pack sugar problems when made into tablets herbal medicine, the majority need to pack sugar (especially the extract tablets). Often encountered in practice the following problems: sticky film isolation layer occurred in the package. The reason is plain film surface brilliance, and a single low temperature by adding an excess syrup, slow evaporation, mixing is not timely, due to adhesion to each other. Measures: First, syrup should be controlled at 40 ℃ ~ 50 ℃, and the proportion of tablets should be 800 to 900 ml / 30 kg. Second, the sugar syrup should be a constant, should be 360 grams / liter. Third,[link widoczny dla zalogowanych], mixing should be timely, uniform, pot temperature maintained at 50 ℃. Exposed edge when the particle water content and more, plus pressure regulator properly, many tablets have flash. After joining the syrup, tablets edge of the flash part of the amount of adhesive syrup and more, the friction coating pan, syrup gradually lost, leading to the edge of plain film revealed. Solution: First, tablets to fully dry, moisture control in the 2% to 3%. Tablets in the sieved to remove small particles, can be a little hard, so that edges removed. Second, it is appropriate to increase the coating layer. Third, proper control of the pot humidity,[link widoczny dla zalogowanych], to avoid excessive water distribution. First, the hardness tablets cracks do not meet the requirements, sizing, the water penetration within the tablets, when the plain film coating layer is greater than the tension surface tension, there may be cracking. Second, poor quality talc, carbonates, after coating by the placement, carbonate reacts with the acid extract carbon dioxide, resulting in film cracking clothing. Solution: First, the hardness of tablets to moderate, reducing the infiltration of water coating process, in addition to controlling the amount of talc syrup together, but also pay attention to regulate the temperature of the pot, so many thin quick drying. Second, the choice of good quality medical talc. Third, product-packing, to ensure airtight moisture. Stain the causes, one soluble pigment migration occurs during the drying process, and second, when the paste-sided rugged, three o'clock when the chip temperature is too high color (this time the temperature is not easy 超过 40 ℃). Fourth, the uneven deployment or paste dosage of each month. Solution: use of insoluble pigments, such as \; light paste pull \Tableting and coating process issues that may arise and solutions loose pieces: tablet hardness increase is not enough binder 3.1.2 3.1.1 adjustment pressures. Sticky red: too much water, improper use of lubricants, surface roughness and punch in the workplace too much moisture. Slow collapse: collapse of improper dosage, excessive amount of lubricant, binder viscosity is too strong, too much pressure and so on. Lobes: the inappropriate choice of adhesives, powder too much, too much pressure and so on. Tablet weight difference is too large: uneven particle size, not down under the red and flexible. Discoloration or stain: strong particles, uneven mixing and so on. Ma points: the amount of improper lubricants and adhesives, particulate lead wet damp, uneven particle size, coarse or fine powder quantity, punch surface roughness. Lamination: a film damper to adjust properly, sticky film on the red and so on. Non-stick syrup (sugar): the wall of wax pot is not divisible by (wash pot wall, or apply a layer of hot syrup,[link widoczny dla zalogowanych], sprinkle a layer of talcum powder.) Uneven color (sugar): one-sided rough, and not too small amount of colored syrup mix; temperature is too high, drying too fast, too fast syrup precipitated in one-sided, clothing layer of wax polish is dry on the increase (for reasons to be addressed .) One-sided inequality (sugar): too much powder, the temperature is too high to pack clothing layers the second layer is dry (to improve methods of operation, to achieve low-temperature drying, engage in active material, more mixing). Blister (thin film coat): improper curing conditions, drying too fast (master film conditions,[link widoczny dla zalogowanych], control the drying temperature and speed). Intestinal insoluble (row pieces) (enteric coating): the inappropriate choice of clothing, clothing layers thick, storage deterioration (for reasons, a reasonable solution). Cockle (film clothing): Select clothing properly, improper drying conditions (replacement of clothing, to improve the film-forming temperature). Can not safely through the stomach (enteric coating): the inappropriate choice of clothing, clothing layer is too thin, the mechanical strength is not enough clothing layer (select clothing, re-adjust the coating formulation). All information in this column are the original site, reproduced please specify \ More articles related to topics:
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